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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Bone Turnover Markers
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Systematic Review / Meta-analysis Evidence High

Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis.

Frontiers in endocrinology | 2024 | Wang F, Wei W, Liu PJ

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 9. Endocr Metab Immune Disord Drug Targets. 2019;19(7):895-912. doi: 10.2174/1871530319666190204165207. Biomarkers of Osteoporosis: An Update. Parveen B(...

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PubMed Randomized Controlled Trial Evidence High

One versus 2 years of alendronate following denosumab: the CARD extension.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2024 | Tsai JN, Jordan M, Lee H, Leder BZ

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Conflicts of interest: JNT has a financial interest in Amgen. JNT’s interests were reviewed and are managed by Massachusetts General Hospital and Mass General Brigham in accordance with their conflict-of-interest policies. All other authors have no conflicts of interest to declare. 15. Wien Klin Wochenschr. 202...

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PubMed Systematic Review / Meta-analysis Evidence High

B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2024 | Luo Y, Zheng S, Jiang S, Yang G

[Indexed for MEDLINE] 19. Osteoporos Int. 2025 Dec;36(12):2459-2469. doi: 10.1007/s00198-025-07722-8. Epub 2025 Oct 13. ROMosozumab early experience in female patients with severe osteoporosis in an Italian real-world setting, the ROMEO study. Adami G(1), Bartezaghi M(2), Montanari F(3), Piccinelli A(3), Pollastri F(3), Mastropaolo F(3), Giorgio F(3), Benini C(3), Fassio A(3),...

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PubMed Systematic Review / Meta-analysis Evidence High

Osteoglycin and Bone-a Systematic Review.

Current osteoporosis reports | 2019 | Starup-Linde J, Viggers R, Handberg A

[Indexed for MEDLINE] 6. Int J Mol Sci. 2024 Apr 26;25(9):4717. doi: 10.3390/ijms25094717. Circadian Regulation of Bone Remodeling. Kikyo N(1)(2). Author information: (1)Stem Cell Institute, Minneapolis, MN 55455, USA. (2)Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Adult bones are continuously remodeled by the bala...

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PubMed Narrative Review Evidence Moderate

Bone metabolism in primary hyperparathyroidism.

Wiener klinische Wochenschrift | 2026 | Kerschan-Schindl K, Gelles K, Butylina M, Crevenna R

[Indexed for MEDLINE] Conflict of interest statement: Conflict of interest: Regarding this manuscript, K. Kerschan-Schindl has received financial support from Servier Austria GmbH to conduct the study evaluating the efficacy of strontium after parathyroidectomy [80]. P. Pietschmann has received research support and/or honoraria from Amgen GmbH, Fresenius Kabi Austria GmbH, Shir...

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PubMed Narrative Review Evidence Moderate

Circadian Regulation of Bone Remodeling.

International journal of molecular sciences | 2024 | Kikyo N

[Indexed for MEDLINE] Conflict of interest statement: The author declares no conflict of interest. 7. Clin Biochem. 2014 Jul;47(10-11):950-9. doi: 10.1016/j.clinbiochem.2014.03.026. Epub 2014 Apr 12. Osteoporosis in men. Korpi-Steiner N(1), Milhorn D(1), Hammett-Stabler C(2). Author information: (1)Department of Pathology and Laboratory Medicine, University of North Carolina, C...

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PubMed Narrative Review Evidence Moderate

Bone turnover markers to monitor oral bisphosphonate therapy.

Cleveland Clinic journal of medicine | 2023 | Ashcherkin N, Patel AA, Algeciras-Schimnich A, Doshi KB

[Indexed for MEDLINE] 18. Osteoporos Int. 2024 Sep;35(9):1645-1659. doi: 10.1007/s00198-024-07150-0. Epub 2024 Jul 2. B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials. Luo Y(1)(2)(3), Zheng S(1)(2)(3), Jiang S(4), Yang G(1)(2), Pavel V(5), Ji H(1)(2), Zhou S(1)(2), Bao Y(3), Xiao W(6)(7), Li Y(8)(9). Author information:...

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PubMed Systematic Review / Meta-analysis Evidence High

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2011 | Vasikaran S, Eastell R, Bruyère O, Foldes AJ

[Indexed for MEDLINE] 11. J Clin Densitom. 2021 Jan-Mar;24(1):1-2. doi: 10.1016/j.jocd.2020.12.002. Epub 2020 Dec 13. Bone Turnover Markers: A New Year Resolution? Hamdy RC. DOI: 10.1016/j.jocd.2020.12.002

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PubMed Narrative Review Evidence Moderate

Biomarkers of Osteoporosis: An Update.

Endocrine, metabolic & immune disorders drug targets | 2019 | Parveen B, Parveen A, Vohora D

[Indexed for MEDLINE] 10. Osteoporos Int. 2011 Feb;22(2):391-420. doi: 10.1007/s00198-010-1501-1. Epub 2010 Dec 24. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Vasikaran S(1), Eastell R, Bruyère O, Foldes AJ, Garnero P, Griesmacher A, McClung M, Morris HA, Silverman S, Trent...

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PubMed Narrative Review Evidence Moderate

Bone turnover: Biology and assessment tools.

Best practice & research. Clinical endocrinology & metabolism | 2018 | Szulc P

[Indexed for MEDLINE] 13. Osteoporos Int. 2024 Sep;35(9):1669-1675. doi: 10.1007/s00198-024-07139-9. Epub 2024 Jun 5. A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis. Kumar S(1)(2)(3), Gild ML(2)(3), McDonald MM(4)(5), Kim AS(1)(4)(5), Clifton-Bligh RJ(2)(3), Girgis CM(6)(7). Author information: (1)Department of Diabe...

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PubMed Narrative Review Evidence Moderate

Use of bone turnover markers in postmenopausal osteoporosis.

The lancet. Diabetes & endocrinology | 2017 | Eastell R, Szulc P

[Indexed for MEDLINE] 3. Baillieres Clin Rheumatol. 1997 Aug;11(3):517-37. doi: 10.1016/s0950-3579(97)80018-0. Bone markers. Garnero P(1), Delmas PD. Author information: (1)INSERM Research Unit 403, Hôpital E. Herriot, Lyon, France. The recent development of specific and sensitive biochemical markers reflecting the overall rate of bone formation and bone resorption, has markedl...

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PubMed Narrative Review Evidence Moderate

Osteoporosis in men.

Clinical biochemistry | 2014 | Korpi-Steiner N, Milhorn D, Hammett-Stabler C

[Indexed for MEDLINE] 8. Front Endocrinol (Lausanne). 2024 Nov 1;15:1487998. doi: 10.3389/fendo.2024.1487998. eCollection 2024. Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis. Wang F(1), Wei W(1), Liu PJ(1). Author information: (1)Department of Clinical Nutrition, Peking Union Medical College Hospital, China Ac...

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PubMed Case Report / Series Evidence Low

A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2024 | Kumar S, Gild ML, McDonald MM, Kim AS

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests. 14. Osteoporos Int. 2024 Dec;35(12):2225-2230. doi: 10.1007/s00198-024-07213-2. Epub 2024 Aug 7. One versus 2 years of alendronate following denosumab: the CARD extension. Tsai JN(1), Jordan M(2), Lee H(3), Leder BZ(2). Author information: (1)Department of Medicine, Endocrine Unit,...

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PubMed Narrative Review Evidence Moderate

Bone turnover markers.

Australian family physician | 2013 | Coates P

[Indexed for MEDLINE] 5. Curr Osteoporos Rep. 2019 Oct;17(5):250-255. doi: 10.1007/s11914-019-00523-z. Osteoglycin and Bone-a Systematic Review. Starup-Linde J(1)(2), Viggers R(3), Handberg A(4)(5). Author information: (1)Department of Medicine, Horsens Regional Hospital, Sundvej 30, 8700, Horsens, Denmark. jakolind@rm.dk. (2)Department of Endocrinology and Internal Medicine, A...

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PubMed Narrative Review Evidence Moderate

[Biomarkers of bone remodelling].

Bulletin du cancer | 2013 | Debiais F

[Indexed for MEDLINE]

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PubMed Original Article Evidence Unclassified

ROMosozumab early experience in female patients with severe osteoporosis in an Italian real-world setting, the ROMEO study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2025 | Adami G, Bartezaghi M, Montanari F, Piccinelli A

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethical approval and consent to participate: The study was conducted according to the protocol RWE0988 approved by our local Ethics Committee, in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was collected for each participant. Consent f...

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Crossref Journal Article Evidence Unclassified

The Treatment and Monitoring of Osteoporosis using Bone Turnover Markers

Orthopedic Reviews | 2025 | Nikhil Patel, Latha Ganti

Osteoporosis is a degenerative bone disease that causes the weakening of bone structure. Since bone structure is dynamic throughout a person’s lifespan, bones are under constant growth and destruction in a process known as bone turnover or bone remodeling. Osteoporosis involves the disruption of this growth/destruction equilibrium towards the destructive side. An increase in bo...

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Crossref Scholarly Work Evidence Unclassified

Biochemical markers of bone turnover: the Study of Osteoporotic Fracture

Bone Markers | 2024 | Douglas C Bauer

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Crossref Scholarly Work Evidence Unclassified

Variation in biochemical markers of bone turnover: sources, quantification, minimization

Bone Markers | 2024 | G Russell Warnick

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Crossref Scholarly Work Evidence Unclassified

Biochemical markers of bone turnover as predictors of bone loss and response to therapy

Bone Markers | 2024 | Clifford J Rosen

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PubMed Narrative Review Evidence Moderate

Osteoporosis.

Lancet (London, England) | 2006 | Sambrook P, Cooper C

[Indexed for MEDLINE] 2. Lancet Diabetes Endocrinol. 2017 Nov;5(11):908-923. doi: 10.1016/S2213-8587(17)30184-5. Epub 2017 Jul 7. Use of bone turnover markers in postmenopausal osteoporosis. Eastell R(1), Szulc P(2). Author information: (1)Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK. Electronic address: r.eastell@sheffield.ac.uk. (2)INSERM UMR 1033,...

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PubMed Original Article Evidence Unclassified

Bone Turnover Markers: A New Year Resolution?

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry | 2021 | Hamdy RC

[Indexed for MEDLINE] 12. Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):725-738. doi: 10.1016/j.beem.2018.05.003. Epub 2018 May 26. Bone turnover: Biology and assessment tools. Szulc P(1). Author information: (1)INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Place d'Arsonval, 69437, Lyon, France. Electronic address: pawel.szulc@inserm.fr. Bone turnover inc...

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PubMed Original Article Evidence Unclassified

Advances in bone turnover markers.

Advances in clinical chemistry | 2021 | Di Medio L, Brandi ML

[Indexed for MEDLINE] 17. Cleve Clin J Med. 2023 Jan 3;90(1):26-31. doi: 10.3949/ccjm.90a.22002. Bone turnover markers to monitor oral bisphosphonate therapy. Ashcherkin N(1), Patel AA(1), Algeciras-Schimnich A(2), Doshi KB(3). Author information: (1)Department of Medicine, Mayo Clinic, Scottsdale, AZ. (2)Professor of Laboratory Medicine and Pathology, Department of Laboratory...

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Crossref Journal Article Evidence Unclassified

Associations between bone turnover markers and bone mineral density in older adults

Journal of Orthopaedic Surgery | 2021 | Zhongxin Zhu, Hongliang Zhou, Yanfei Wang, Xiaocong Yao

Objective: To examine the associations between bone turnover markers (BTMs) and bone mineral density (BMD) in older adults aged 60–85 years. Methods: A total of 1124 men (mean age, 69.1 years) and 1203 women (mean age, 70.7 years) from the National Health and Nutrition Examination Survey 1999–2002 were included in this cross-sectional analysis. Independent variables were serum...

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Crossref Journal Article Evidence Unclassified

Bone Turnover Markers and Bone Mineral Density to Predict Osteoporotic Fractures in Older Women: A Retrospective Comparative Study

Orthopaedic Surgery | 2020 | Xiao‐long Qu, Bo Zheng, Tian‐yi Chen, Zong‐rui Cao

ObjectiveTo investigate the clinical significance of the detection of bone mineral density (BMD) and bone turnover markers (BTM) in older women with osteoporosis, and to compare their predictive power for osteoporotic fractures (OF).MethodsIn this retrospective study, 96 patients with OF and 107 patients with osteoporosis who were hospitalized in the Department of Orthopedics a...

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Crossref Scholarly Work Evidence Unclassified

Bone turnover markers

Principles of Bone Biology | 2020 | Patrick Garnero, Serge Cremers

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Crossref Journal Article Evidence Unclassified

Clinical utility of bone turnover markers

Bone Abstracts | 2013 | Nuria Guanabens

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PubMed Narrative Review Evidence Moderate

Bone markers.

Bailliere's clinical rheumatology | 1997 | Garnero P, Delmas PD

[Indexed for MEDLINE] 4. Aust Fam Physician. 2013 May;42(5):285-7. Bone turnover markers. Coates P(1). Author information: (1)Chemical Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia. penelope.coates@health.sa.gov.au Bones are constantly remodelled to cope with the body's calcium requirements and to repair microscopic damage. The entire skeleto...

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Crossref Journal Article Evidence Unclassified

Serum Levels of Bone Turnover Markers following Total Joint Arthroplasty

Journal of Orthopaedic Surgery | 2011 | Viroj Wiwanitkit

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Crossref Journal Article Evidence Unclassified

Bone turnover markers and bone mineral density in children with haemophilia

Haemophilia | 2011 | A. TLACUILO-PARRA, J. VILLELA-RODRÍGUEZ, R. GARIBALDI-COVARRUBIAS, J. SOTO-PADILLA

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Crossref Journal Article Evidence Unclassified

Comparison in bone turnover markers during early healing of femoral neck fracture and trochanteric fracture in elderly patients

Orthopedic Review | 2009

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Crossref Journal Article Evidence Unclassified

Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty

Journal of Orthopaedic Research | 2003 | J. Mark Wilkinson, Andrew J. Hamer, Angela Rogers, Ian Stockley

AbstractThe aims of this study were to determine whether subjects with aseptic loosening after total hip arthroplasty (THA) have regional differences in periprosthetic bone mineral density (BMD) and systemic biochemical markers of bone turnover compared to subjects with successful implants.Proximal femoral and pelvic BMD were measured by dual energy X‐ray absorptiometry and bon...

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Crossref Journal Article Evidence Unclassified

Working group on biochemical markers of bone turnover

Bone | 1998

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Crossref Scholarly Work Evidence Unclassified

Biochemical markers of bone turnover

Methods in Bone Biology | Simon P. Robins

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Crossref Scholarly Work Evidence Unclassified

Sonographic measures of bone density and markers of bone turnover during pregnancy and lactation

Journal unavailable | Beata Seeber

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