Carbon nanotube-based biomaterials for orthopaedic applications.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] 5. Drug Des Devel Ther. 2024 Aug 26;18:3765-3790. doi: 10.2147/DDDT.S473007. eCollection 2024. Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives. Zhang M(#)(1)(2)(3), Mi M(#)(1)(2)(4), Hu Z(#)(3)(4), Li L(3)(4), Chen Z(1)(2)(3), Gao X(5), Liu D(3)(4), Xu B(3), Liu Y(1)(2)(3). Author information: (1)Zhanjiang Key Laboratory of Orthopaedic Technology and Trauma Treatment, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, 524037, People's Republic of China. (2)Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Infectious Diseases, Guangdong Provincial Administration of Traditional Chinese Medicine (Central People's Hospital of Zhanjiang), Zhanjiang, 524037, People's Republic of China. (3)Marine Medical Research Institute of Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. (4)Guangdong Provincial Key Laboratory for Research and Development of Natural Drug, School of Pharmacy, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. (5)Stem Cell Research and Cellular Therapy Center, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China. (#)Contributed equally Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility and adhesiveness. It can also be engineered into a variety of nanoparticles and biomaterials for drug delivery, functional modification, making it an excellent choice to enhance the prevention and treatment of orthopedic diseases. Currently, the application of polydopamine biomaterials in orthopedic disease prevention and treatment is in its early stages, despite some initial achievements. This article aims to review these applications to encourage further development of polydopamine for orthopedic therapeutic needs. We detail the properties of polydopamine and its biomaterial types, highlighting its superior performance in functional modification on nanoparticles and materials. Additionally, we also explore the challenges and future prospects in developing optimal polydopamine biomaterials for clinical use in orthopedic disease prevention and treatment. © 2024 Zhang et al. DOI: 10.2147/DDDT.S473007 PMCID: PMC11363944