Infection after fracture fixation.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

Conflict of interest statement: ICMJE Conflict of interest statement: AT reports grants from Zimmer Biomet paid to his institution outside the submitted work and travel/accommodation/meeting expenses unrelated to activities listed paid to him by Biocomposites. OB reports board membership paid to his institution by Orthopaedic Society, EBJIS, AO Trauma Switzerland; consultancy paid to his institution by Medacta, Heraeus, Zimmer, Lima; grants/grants pending paid to his institution by Heraeus,Bonesupport, Matthys, AO Trauma Switzerland; payment for lectures including service on speakers bureaus by Medacta, Heraeus, Orthofix, Zimmer, all outside the permitted work. All other authors declare no conflict of interest. 8. Best Pract Res Clin Rheumatol. 2006 Dec;20(6):1045-63. doi: 10.1016/j.berh.2006.08.003. Infection and musculoskeletal conditions: Prosthetic-joint-associated infections. Zimmerli W(1). Author information: (1)Basel University Medical Clinic, Kantonsspital, CH-4410 Liestal, Switzerland. werner.zimmerli@unibas.ch In patients with osteoarthritis or arthritis, prosthetic joint replacement is increasingly used to alleviate pain and to improve mobility. The most important risk factors are comorbidity and prior joint replacement (revision surgery). Diagnosis of prosthetic-joint-associated infection is difficult, because the infecting agent may be missed in synovial fluid due to its exclusive presence as a device-associated biofilm. Implant-associated infections are difficult to treat because of their resistance to natural host defence mechanisms and to most antibiotics. In staphylococcal implant-associated infections a rifampin combination should be used, because this drug has an excellent efficacy on surface-adhering microorganisms. Antimicrobial therapy must always be combined with the correct surgical treatment which is chosen according to an algorithm. The use of antibiotics during procedures with potential bacteraemia is controversial because evidence for its need is lacking. In contrast, during sepsis rapid antibiotic therapy is needed to prevent haematogenous seeding on the artificial joint. DOI: 10.1016/j.berh.2006.08.003