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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Osteoporosis — Pathophysiology and Management
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Guideline / Consensus Evidence High

Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2025 | Bhattoa HP, Vasikaran S, Trifonidi I, Kapoula G

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Conflict of interest: H.P.B.: No conflict of interest; S.V.: No conflict of interest; I.T.: No conflict of interest; G.K.: No conflict of interest; G.L.: Received speaker fee from SNIBE; N.R.J.: Received bone turnover marker assays free of charge for research from ROCHE, IDS and DiaSorin for research purposes;...

PubMed Guideline / Consensus Evidence High

Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.

JAMA | 2025 | US Preventive Services Task Force, Nicholson WK, Silverstein M, Wong JB

[Indexed for MEDLINE] 9. Nephrol Dial Transplant. 2021 Jan 1;36(1):42-59. doi: 10.1093/ndt/gfaa192. European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4-G5D. Evenepoel P(1), Cunningham J(2), Ferrari S(3), Haarhaus M(4)(5), Javaid MK(6), Lafage-Proust MH(7), Prieto-Alhambra D(8), Torres PU(9)(10), Cannata-Andia J(11); E...

PubMed Systematic Review / Meta-analysis Evidence High

Screening for Osteoporosis to Prevent Fractures: A Systematic Evidence Review for the US Preventive Services Task Force.

JAMA | 2025 | Kahwati LC, Kistler CE, Booth G, Sathe N

[Indexed for MEDLINE] Conflict of interest statement: Conflict of interest disclosures: None reported. 17. Radiol Clin North Am. 1991 Jan;29(1):77-84. Osteoporosis. Gillespy T 3rd(1), Gillespy MP. Author information: (1)Department of Radiology, University of Florida, Gainesville. Osteoporosis, a condition of decreased bone tissue that increases the likelihood of fracture, place...

PubMed Guideline / Consensus Evidence High

European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4-G5D.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 2021 | Evenepoel P, Cunningham J, Ferrari S, Haarhaus M

[Indexed for MEDLINE] 10. Med Clin North Am. 1987 Jan;71(1):41-57. doi: 10.1016/s0025-7125(16)30881-1. Postmenopausal osteoporosis. Silverberg SJ, Lindsay R. Osteoporosis is a major public health problem, particularly for the postmenopausal woman. With the withdrawal of estrogen at menopause, bone resorption begins to exceed formation in remodeling cycles and bone mass is inexo...

PubMed Guideline / Consensus Evidence High

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2019 | Kanis JA, Cooper C, Rizzoli R, Reginster JY

[Indexed for MEDLINE] Conflict of interest statement: JAK reports grants from Amgen, Eli Lilly and Radius Health; non-financial support from Medimaps, and Asahi; and other support from AgNovos. JAK is the architect of FRAX® but has no financial interest. CC reports personal fees from Alliance for Better Bone Health, Amgen, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfizer, Roc...

PubMed Randomized Controlled Trial Evidence High

Bone mineral density gains with a second 12-month course of romosozumab therapy following placebo or denosumab.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2019 | Kendler DL, Bone HG, Massari F, Gielen E

[Indexed for MEDLINE] Conflict of interest statement: DLK has been an investigator for Amgen, Astellas, AstraZeneca, and Eli Lilly; a speaker and consultant for Amgen, Pfizer, and Eli Lilly; and a member of a drug safety advisory board for Merck. HGB has been an investigator for Amgen, Merck, and Shire; a consultant for Amgen, Merck, Radius Health, and Shire; a speaker for Amge...

PubMed Narrative Review Evidence Moderate

Osteoporosis: A Review.

JAMA | 2025 | Morin SN, Leslie WD, Schousboe JT

[Indexed for MEDLINE] 2. Clin Geriatr Med. 2002 Aug;18(3):529-55. doi: 10.1016/s0749-0690(02)00022-8. Osteoporosis in elderly: prevention and treatment. Srivastava M(1), Deal C. Author information: (1)Section of Geriatric Medicine, A91 Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Osteoporosis is a major clinical problem in older women and men. Almo...

PubMed Randomized Controlled Trial Evidence High

Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial.

Lancet (London, England) | 2015 | Leder BZ, Tsai JN, Uihlein AV, Wallace PM

[Indexed for MEDLINE] 7. Osteoporos Int. 2025 Apr;36(4):579-608. doi: 10.1007/s00198-025-07422-3. Epub 2025 Mar 28. Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporo...

PubMed Guideline / Consensus Evidence High

The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2014 | Siris ES, Adler R, Bilezikian J, Bolognese M

[Indexed for MEDLINE] 16. JAMA. 2025 Feb 11;333(6):509-531. doi: 10.1001/jama.2024.21653. Screening for Osteoporosis to Prevent Fractures: A Systematic Evidence Review for the US Preventive Services Task Force. Kahwati LC(1)(2), Kistler CE(3), Booth G(1)(2), Sathe N(1)(2), Gordon RD(4), Okah E(5), Wines RC(1)(2), Viswanathan M(1)(2). Author information: (1)RTI International-Uni...

PubMed Narrative Review Evidence Moderate

Update on Osteoporosis Screening and Management.

The Medical clinics of North America | 2021 | Anam AK, Insogna K

[Indexed for MEDLINE] Conflict of interest statement: Disclosure The authors have nothing to disclose. 5. J Steroid Biochem Mol Biol. 2014 Jul;142:155-70. doi: 10.1016/j.jsbmb.2013.09.008. Epub 2013 Oct 29. Prevention and treatment of postmenopausal osteoporosis. Tella SH(1), Gallagher JC(2). Author information: (1)Internal Medicine, Creighton University School of Medicine, 601...

PubMed Narrative Review Evidence Moderate

Update on Osteoporosis.

Primary care | 2019 | Yedavally-Yellayi S, Ho AM, Patalinghug EM

[Indexed for MEDLINE] 14. Curr Osteoporos Rep. 2013 Mar;11(1):30-5. doi: 10.1007/s11914-012-0127-y. Obesity and bone. Compston J(1). Author information: (1)Department of Medicine, Addenbrooke's Hospital, Box 157, Level 5, Hills Road, Cambridge CB2 0QQ, UK. jec1001@cam.ac.uk Recent studies indicate that fractures in obese postmenopausal women and older men contribute significant...

PubMed Narrative Review Evidence Moderate

Prevention and treatment of postmenopausal osteoporosis.

The Journal of steroid biochemistry and molecular biology | 2014 | Tella SH, Gallagher JC

[Indexed for MEDLINE] 6. Lancet. 2015 Sep 19;386(9999):1147-55. doi: 10.1016/S0140-6736(15)61120-5. Epub 2015 Jul 2. Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial. Leder BZ(1), Tsai JN(2), Uihlein AV(2), Wallace PM(2), Lee H(3), Neer RM(2), Burnett-Bowie SA(2). Author information: (1)Dep...

PubMed Narrative Review Evidence Moderate

Obesity and bone.

Current osteoporosis reports | 2013 | Compston J

[Indexed for MEDLINE] 15. Osteoporos Int. 2014 May;25(5):1439-43. doi: 10.1007/s00198-014-2655-z. Epub 2014 Feb 28. The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Siris ES(1), Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Khosla S, Lane NE, Lindsay R, Nana AD, Orwoll...

PubMed Narrative Review Evidence Moderate

Denosumab update.

Current opinion in rheumatology | 2009 | Lewiecki EM

[Indexed for MEDLINE] 12. JNMA J Nepal Med Assoc. 2005 Apr-Jun;44(158):60-6. Osteoporosis-an update. Lamichhane AP(1). Author information: (1)TU Teaching Hospital, Maharajgunj, Kathmandu, Nepal. dr_ajun@yahoo.com Osteoporosis is a systemic disease characterized by decrease in bone mass per unit volume, compromised bone strength, which predisposes the affected bone to fracture....

Crossref Scholarly Work Evidence Unclassified

Immunomodulation of Bone Remodeling in Osteoporosis

Osteoporosis - Pathophysiology, Diagnosis, Management and Therapy | 2023 | Sayantee Hazra, Shagnik Chattopadhyay, Ritobrata Goswami

Reducing bone density and bone quality with increasing propensity of skeletal fracture are the main symptoms of osteoporosis. Disruption of the fine balance between bone formation and resorption leads to this progressive condition, which affects 50% of women and 30% of men after the age of 50. Aging, reduced nutrient (vitamin D and calcium) uptake, suppressed production of estr...

Crossref Scholarly Work Evidence Unclassified

Drug Therapeutics of Osteoporosis, Vertebral Fracture and Nonunion

Osteoporosis - Pathophysiology, Diagnosis, Management and Therapy | 2023 | Pengguo Gou, Feng Chang

Osteoporosis management is effective in decreasing vertebral fracture risk. The assessment of vertebral fracture risk is used to identify patients with high fracture risk for anti-osteoporotic treatment, especially for those who have not yet fractured. Several pharmacological agents are available to lower vertebral fracture risk by reducing bone resorption or/and stimulating bo...

PubMed Narrative Review Evidence Moderate

Glucocorticoid-induced osteoporosis.

Current opinion in endocrinology, diabetes, and obesity | 2007 | Berris KK, Repp AL, Kleerekoper M

[Indexed for MEDLINE] 20. Expert Opin Pharmacother. 2016;17(4):473-88. doi: 10.1517/14656566.2016.1124856. Epub 2015 Dec 23. Management of severe osteoporosis. Miller PD(1). Author information: (1)a University of Colorado Health Sciences Center , Colorado Center for Bone Research , Lakewood , CO , USA. INTRODUCTION: Severe osteoporosis represents a disease of high mortality and...

PubMed Narrative Review Evidence Moderate

Osteoporosis-an update.

JNMA; journal of the Nepal Medical Association | 2005 | Lamichhane AP

[Indexed for MEDLINE] 13. Prim Care. 2019 Mar;46(1):175-190. doi: 10.1016/j.pop.2018.10.014. Epub 2018 Dec 24. Update on Osteoporosis. Yedavally-Yellayi S(1), Ho AM(2), Patalinghug EM(2). Author information: (1)Department of Family Medicine, Family Medicine Residency Program, Beaumont Health Troy, 44250 Dequindre Road, Sterling Heights, MI 48314, USA; Oakland University William...

PubMed Narrative Review Evidence Moderate

Osteoporosis in elderly: prevention and treatment.

Clinics in geriatric medicine | 2002 | Srivastava M, Deal C

[Indexed for MEDLINE] 3. Osteoporos Int. 2019 Jan;30(1):3-44. doi: 10.1007/s00198-018-4704-5. Epub 2018 Oct 15. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Kanis JA(1)(2), Cooper C(3)(4), Rizzoli R(5), Reginster JY(6)(7); Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) an...

PubMed Narrative Review Evidence Moderate

Osteoporosis.

Radiologic clinics of North America | 1991 | Gillespy T 3rd, Gillespy MP

[Indexed for MEDLINE] 18. Osteoporos Int. 2019 Dec;30(12):2437-2448. doi: 10.1007/s00198-019-05146-9. Epub 2019 Oct 18. Bone mineral density gains with a second 12-month course of romosozumab therapy following placebo or denosumab. Kendler DL(1), Bone HG(2), Massari F(3), Gielen E(4), Palacios S(5), Maddox J(6), Yan C(7)(8), Yue S(6)(9), Dinavahi RV(6), Libanati C(10), Grauer A...

PubMed Narrative Review Evidence Moderate

Postmenopausal osteoporosis.

The Medical clinics of North America | 1987 | Silverberg SJ, Lindsay R

[Indexed for MEDLINE] 11. Curr Opin Rheumatol. 2009 Jul;21(4):369-73. doi: 10.1097/BOR.0b013e32832ca41c. Denosumab update. Lewiecki EM(1). Author information: (1)New Mexico Clinical Research & Osteoporosis Center, Albuquerque, New Mexico 87106, USA. LEWIECKI@aol.com PURPOSE OF REVIEW: Denosumab is an investigational fully human monoclonal antibody to receptor activator of nucle...