Aerobic exercise in patients with haemophilia: A systematic review on safety, feasibility and health effects.

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Abstract

[Indexed for MEDLINE] 2. Res Pract Thromb Haemost. 2024 Jan 3;8(1):102314. doi: 10.1016/j.rpth.2023.102314. eCollection 2024 Jan. Ultrasound evaluation of hemophilic arthropathy: a proposal of definitions in a changing landscape. Gualtierotti R(1)(2), Solimeno LP(3), Peyvandi F(1)(2); Ultrasound in hemophilic arthropathy study group. Collaborators: Giachi A, Arcudi S, Ciavarella A, Siboni SM. Author information: (1)Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. (2)Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. (3)Division of Orthopaedic Surgery and Traumatology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. The advent of novel effective treatments and the identification of the need to achieve a higher trough level for persons with hemophilia A and B have changed the landscape of management of these patients, allowing to change the target from survival and prevention of life-threatening complications to prevention of musculoskeletal complications and improvement of quality of life. Point-of-care musculoskeletal ultrasound imaging has also improved the early recognition of joint bleeding and the differential diagnosis of acute joint pain. In addition, joint ultrasound allows the evaluation of the severity of hemophilic arthropathy in terms of synovitis and cartilage and bone damage. However, a lack of standardization in the definition of ultrasound elementary lesions of hemophilic arthropathy may lead to confusion and an incorrect evaluation of the presence and progression of joint damage. Here, we propose to start a standardization and validation process for ultrasound definitions of hemophilic arthropathy that has been planned to become a project within the Factor VIII/IX Standardization Subcommittee of the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee. © 2024 The Author(s). DOI: 10.1016/j.rpth.2023.102314 PMCID: PMC10844857