Obesity and bone.

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Abstract

[Indexed for MEDLINE] 11. JAMA. 2025 Feb 11;333(6):498-508. doi: 10.1001/jama.2024.27154. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force; Nicholson WK(1), Silverstein M(2), Wong JB(3), Chelmow D(4), Coker TR(5), Davis EM(6), Jaén CR(7), Krousel-Wood M(8), Lee S(9), Li L(10), Mangione CM(11), Ogedegbe G(12), Rao G(13), Ruiz JM(14), Stevermer J(15), Tsevat J(7), Underwood SM(16), Wiehe S(17). Author information: (1)George Washington University, Washington, DC. (2)Brown University, Providence, Rhode Island. (3)Tufts University School of Medicine, Boston, Massachusetts. (4)Virginia Commonwealth University, Richmond. (5)University of Washington, Seattle. (6)University of Maryland School of Medicine, Baltimore. (7)University of Texas Health Science Center, San Antonio. (8)Tulane University, New Orleans, Louisiana. (9)University of California, San Francisco. (10)University of Virginia, Charlottesville. (11)University of California, Los Angeles. (12)New York University, New York, New York. (13)Case Western Reserve University, Cleveland, Ohio. (14)University of Arizona, Tucson. (15)University of Missouri, Columbia. (16)University of Wisconsin, Milwaukee. (17)Indiana University, Bloomington. Comment in JAMA. 2025 Feb 11;333(6):468-469. doi: 10.1001/jama.2024.27416. JAMA Netw Open. 2025 Jan 2;8(1):e2460746. doi: 10.1001/jamanetworkopen.2024.60746. AJR Am J Roentgenol. 2025 Aug;225(2):e2532969. doi: 10.2214/AJR.25.32969. IMPORTANCE: Osteoporotic fractures are associated with psychological distress, subsequent fractures, loss of independence, reduced ability to perform activities of daily living, and death. OBJECTIVE: The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the evidence on the benefits and harms of screening for osteoporosis to prevent fractures in adults 40 years or older with no known diagnosis of osteoporosis or history of fragility fracture. POPULATION: Adults 40 years or older without known osteoporosis or history of fragility fractures. EVIDENCE ASSESSMENT: The USPSTF concludes with moderate certainty that screening for osteoporosis to prevent osteoporotic fractures in women 65 years or older has moderate net benefit. The USPSTF concludes with moderate certainty that screening for osteoporosis to prevent osteoporotic fractures in postmenopausal women younger than 65 years at increased risk has moderate net benefit. The USPSTF concludes that the evidence is insufficient and the balance of benefits and harms for screening for osteoporosis to prevent osteoporotic fractures in men cannot be determined. RECOMMENDATION: The USPSTF recommends screening for osteoporosis to prevent osteoporotic fractures in women 65 years or older. (B recommendation) The USPSTF recommends screening for osteoporosis to prevent osteoporotic fractures in postmenopausal women younger than 65 years who are at increased risk for an osteoporotic fracture as estimated by clinical risk assessment. (B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for osteoporosis to prevent osteoporotic fractures in men. (I statement). DOI: 10.1001/jama.2024.27154