Total knee arthroplasty in the face of a previous tuberculosis infection of the knee: what do we know in 2018?

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Abstract

[Indexed for MEDLINE] 18. Sci Rep. 2020 Mar 4;10(1):3975. doi: 10.1038/s41598-020-60464-x. Tibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage. Renault JB(1)(2), Carmona M(3)(4), Tzioupis C(3), Ollivier M(5)(3), Argenson JN(5)(3), Parratte S(5)(3)(6), Chabrand P(5)(3). Author information: (1)Aix Marseille Univ, CNRS, ISM, Marseille, France. jean-baptiste.renault@univ-amu.fr. (2)APHM, Institute for Locomotion, Department of orthopaedics and Traumatology, Sainte-Marguerite Hospital, 13009, Marseille, France. jean-baptiste.renault@univ-amu.fr. (3)APHM, Institute for Locomotion, Department of orthopaedics and Traumatology, Sainte-Marguerite Hospital, 13009, Marseille, France. (4)Department of Orthopaedics and Traumatology, Pontificia Universidad Católica de Chile, Santiago, Chile. (5)Aix Marseille Univ, CNRS, ISM, Marseille, France. (6)International Knee And Joint Center, Abu Dhabi, United Arab Emirates. At advanced knee osteoarthritis (OA) stages subchondral trabecular bone (STB) is altered. Lower limb alignment plays a role in OA progression and modify the macroscopic loading of the medial and lateral condyles of the tibial plateau. How the properties of the STB relate to alignment and OA stage is not well defined. OA stage (KL scores 2-4) and alignment (HKA from 17° Varus to 8° Valgus) of 30 patients were measured and their tibial plateau were collected after total knee arthroplasty. STB tissue elastic modulus, bone volume fraction (BV/TV) and trabecula thickness (Tb.Th) were evaluated with nanoindentation and µCT scans (8.1 µm voxel-size) of medial and lateral samples of each plateau. HKA and KL scores were statistically significantly associated with STB elastic modulus, BV/TV and Tb.Th. Medial to lateral BV/TV ratio correlated with HKA angle (R = -0.53, p = 0.016), revealing a higher ratio for varus than valgus subjects. STB properties showed lower values for KL stage 4 patients. Tissue elastic modulus ratios and BV.TV ratios were strongly correlated (R = 0.81, p