Tibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests. 19. Front Endocrinol (Lausanne). 2023 Jan 11;13:1021083. doi: 10.3389/fendo.2022.1021083. eCollection 2022. The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study. Jiang L(1)(2), Jiang Y(3), Wang A(4), Wu C(5), Shen Y(6). Author information: (1)Department of Prevention Medicine, College of Public health, Shanghai University of Medicine & Health Sciences, Shanghai, China. (2)Jiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China. (3)Department of Health, Center for Disease Control and Prevention in Suqian, Suqian, Jiangsu Province, China. (4)Department of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, China. (5)Department of Non-communicable Disease, Baoshan District Center for Disease Control and Prevention in Shanghai, Shanghai, China. (6)Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu Province, China. OBJECTIVES: The causal direction and magnitude of the association between total body bone mineral density (TB-BMD) and osteoarthritis (OA) risk is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. The study aimed to explore the relationships between TB-BMD concentration and OA using Mendelian randomization (MR). METHODS: In this study, we used two-sample MR to obtain unconfounded estimates of the effect of TB-BMD on hip and knee OA. Single nucleotide polymorphisms (SNPs) strongly associated with TB-BMD in a large genome-wide association study (GWAS) were identified and selected as instrumental variables (IVs). In addition to the main analysis using inverse-variance weighted (IVW) method, we applied 2 additional methods to control for pleiotropy(MR-Egger regression, weighted median estimator) and compared the respective MR estimates. RESULTS: MR analyses suggested that genetically predicted higher TB-BMD is associated with risks of hip OA (For IVW: OR=1.199, 95%CI: 1.02-1.42, P=0.032; for WM: OR=1.257, 95%CI: 1.09-1.45, P=0.002). There was no evidence that the observed causal effect between TB-BMD and the risk of hip OA was affected by genetic pleiotropy(P=0.618). Additionally, our study didn't support causal effects of a genetically increased TB-BMD risk on knee OA risk(OR=1.121, 95%CI: 0.99-1.28, P=0.084 using IVW; OR=1.132, 95%CI: 0.99-1.29, P=0.068 using WM; OR=1.274, 95%CI: 0.88-1.85, P=0.217 using MR-Egger). CONCLUSIONS: Our findings support a causal effect that a genetic predisposition to systematically higher TB-BMD was associated with the risk of OA. And, TB-BMD likely exerts an effect on the risk of hip OA not knee OA. Copyright © 2023 Jiang, Jiang, Wang, Wu and Shen. DOI: 10.3389/fendo.2022.1021083 PMCID: PMC9874138