Prophylactic antibiotics for massive endoprostheses in orthopaedic oncology.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests. J. F. Standing reports research grants from the Medical Research Council (MRC), the Wellcome Trust, National Institute for Health and Care Research (NIHR), and Great Ormond Street Hospital (GOSH), consulting fees paid to their institution from Adrenomed, Proveca, and ClinSearch, and participation on a data safety monitoring board or advisory board for GSK, all of which are unrelated to this study. C. Gerrand reports institutional funding from Stryker, which is unrelated to this study. 17. Infect Dis Clin North Am. 2017 Jun;31(2):253-263. doi: 10.1016/j.idc.2017.01.011. Epub 2017 Mar 11. Prevention of Infection in Orthopedic Prosthetic Surgery. Chirca I(1), Marculescu C(2). Author information: (1)Department of infectious Diseases, University Hospital, 1350 Walton Way, Augusta, GA 30909, USA. (2)Division of Infectious Diseases, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA. Electronic address: marcule@musc.edu. Total joint arthroplasty is a generally safe orthopedic procedure; however, infection is a potentially devastating complication. Multiple risk factors have been identified for development of prosthetic joint infections. Identification of patients at risk and preoperative correction of known risk factors, such as smoking, diabetes mellitus, anemia, malnutrition, and decolonization of Staphylococcus carriers, represent well-established actions to decrease the infection risk. Careful operative technique, proper draping and skin preparation, and appropriate selection and dosing of antimicrobials for perioperative prophylaxis are also very important in prevention of infection. Published by Elsevier Inc. DOI: 10.1016/j.idc.2017.01.011