Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: This is an investigator-initiated independent research study supported, in part, by BioMarin, Inc. The data presented in this paper do not pertain to the investigational pharmaceuticals under development by BioMarin, Ascendis, Therachon, or QED. These following competing activities were reviewed and approved by our institutions. J.E.H.-F. has participated in Advisory Boards sponsored by BioMarin pertaining to achondroplasia. J.E.H.-F. has been consulted by BioMarin, Alexion, Therachon/Pfizer, QED, Innoskel and NovoNordisk for clinical issues related to achondroplasia and other genetic skeletal conditions and acts as a site principal investigator (PI) for clinical trials for BioMarin, Therachon/Pfizer and QED. M.B.B. has participated in Advisory Boards sponsored by BioMarin, consulted with BioMarin, Ascendis, Therachon/Pfizer, and QED for clinical issues related achondroplasia as well as acting as a site PI in their clinical trials. He is a member of Alexion’s Speaker’s Bureau (HPP). M.B.B. is a site PI and consultant for MedLife Discoveries (RCDP) and Ultragenyx. He is a site PI for Shire (Hunter). J.T.H. has participated in Advisory Boards pertaining to achondroplasia sponsored by BioMarin. D.R.-B. has participated in Advisory Boards pertaining to achondroplasia sponsored by BioMarin and has lectured for BioMarin. J.L. is a site PI for Ascendis and is a paid speaker for BioMarin. The other authors declare no competing interests. 5. J Clin Orthop Trauma. 2025 Oct 13;71:103239. doi: 10.1016/j.jcot.2025.103239. eCollection 2025 Dec. Anesthetic management of children undergoing specialized orthopedic surgeries. Choudhry DK(1), Oommen A(2)(3), Purohit M(2), Dixit D(2)(3). Author information: (1)Department of Anesthesiology, Shriners Children's Philadelphia, Pennsylvania, USA. (2)Department of Anesthesiology and Perioperative Medicine, Nemours Children's Health, Wilmington, Delaware, USA. (3)Departments of Anesthesiology and Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Children with musculoskeletal disorders frequently undergo surgical procedures requiring specialized need and care from an anesthetic perspective. In this review, we discuss anesthetic issues relating to some of the common orthopedic conditions amongst children that warrant knowledge, familiarity, and skills to provide safe anesthetic care for optimal outcome. We have included cerebral palsy, osteogenesis imperfecta, arthrogryposis multiplex congenita, and achondroplasia in this spectrum of review. The scope of this review encompasses existing medical literature and institutional experience gathered from administering anesthesia in a large volume of specialized orthopedic pediatric patients. We have provided an overview of the various perioperative considerations of the above-mentioned select pediatric orthopedic conditions to facilitate safe anesthetic management. © 2025 Delhi Orthopedic Association. All rights are reserved, including those for text and data mining, AI training, and similar technologies. DOI: 10.1016/j.jcot.2025.103239 PMCID: PMC12569809