Editorial Commentary: Offloading Patellofemoral Chondral Defects Requires Tailored Tibial Tuberosity Osteotomy Procedures.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Disclosures The author declares the following financial interests/personal relationships which may be considered as potential competing interests: M.J.T. has consulting or advisory relationships with Arthrex, Johnson and Johnson, Vericel, and Verywell Health; is a board member of the American Orthopaedic Society for Sports Medicine and the AO Foundation; has received funding grants from Voice in Sport, the Arthroscopic Association of North America, and Fujifilm Corporation; and is an editorial board member of Arthroscopy. 7. Polymers (Basel). 2023 May 18;15(10):2360. doi: 10.3390/polym15102360. Intraarticular Implantation of Autologous Chondrocytes Placed on Collagen or Polyethersulfone Scaffolds: An Experimental Study in Rabbits. Płończak M(1), Wasyłeczko M(2), Jakutowicz T(3), Chwojnowski A(2), Czubak J(4). Author information: (1)Mazovia Regional Hospital John Paul II, 08-110 Siedlce, Poland. (2)Nałęcz Institute of Biocybernetic and Biomedical Engineering, Polish Academy of Sciences, 02-109 Warsaw, Poland. (3)Department of Neurosurgery and Children Traumatology, Medical University of Warsaw, 02-091 Warsaw, Poland. (4)Department of Orthopedics, Pediatric Orthopedics and Traumatology, Centre of Postgraduate Medical Education, Gruca Orthopaedic and Trauma Teaching Hospital, 05-402 Otwock, Poland. Hyaline cartilage has very limited repair capability and cannot be rebuilt predictably using conventional treatments. This study presents Autologous Chondrocyte Implantation (ACI) on two different scaffolds for the treatment of lesions in hyaline cartilage in rabbits. The first one is a commercially available scaffold (Chondro-Gide) made of collagen type I/III and the second one is a polyethersulfone (PES) synthetic membrane, manufactured by phase inversion. The revolutionary idea in the present study is the fact that we used PES membranes, which have unique features and benefits that are desirable for the 3D cultivation of chondrocytes. Sixty-four White New Zealand rabbits were used in this research. Defects penetrating into the subchondral bone were filled with or without the placement of chondrocytes on collagen or PES membranes after two weeks of culture. The expression of the gene encoding type II procollagen, a molecular marker of chondrocytes, was evaluated. Elemental analysis was performed to estimate the weight of tissue grown on the PES membrane. The reparative tissue was analyzed macroscopically and histologically after surgery at 12, 25, and 52 weeks. RT-PCR analysis of the mRNA isolated from cells detached from the polysulphonic membrane revealed the expression of type II procollagen. The elementary analysis of polysulphonic membrane slices after 2 weeks of culture with chondrocytes revealed a concentration of 0.23 mg of tissue on one part of the membrane. Macroscopic and microscopic evaluation indicated that the quality of regenerated tissue was similar after the transplantation of cells placed on polysulphonic or collagen membranes. The established method for the culture and transplantation of chondrocytes placed on polysulphonic membranes resulted in the growth of the regenerated tissue, revealing the morphology of hyaline-like cartilage to be of similar quality to collagen membranes. DOI: 10.3390/polym15102360 PMCID: PMC10221810