In Vitro Comparison of 2 Clinically Applied Biomaterials for Autologous Chondrocyte Implantation: Injectable Hydrogel Versus Collagen Scaffold.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors declare no conflict of interest. PB and MH declare that the clinical products investigated in this study are clinically used by PB and MH. KB is head of the research and development department of TETEC Tissue Engineering Technologies AG. KB had no role in the design of the study; in the collection, analyses, or interpretation of data; or in the decision to publish the results. 15. EFORT Open Rev. 2020 Mar 2;5(3):156-163. doi: 10.1302/2058-5241.5.190031. eCollection 2020 Mar. Current solutions for the treatment of chronic articular cartilage defects in the knee. Chimutengwende-Gordon M(1), Donaldson J(1), Bentley G(1). Author information: (1)Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK. Chondral and osteochondral defects in the knee are common and may lead to degenerative joint disease if treated inappropriately.Conventional treatments such as microfracture often result in fibrocartilage formation and are associated with inferior results. Additionally, microfracture is generally unsuitable for the treatment of defects larger than 2-4 cm2.The osteochondral autograft transfer system (OATS) has been shown to produce superior clinical outcomes to microfracture but is technically difficult and may be associated with donor-site morbidity. Osteochondral allograft use is limited by graft availability and failure of cartilage incorporation is an issue.Autologous chondrocyte implantation (ACI) has been shown to result in repair with hyaline-like cartilage but involves a two-stage procedure and is relatively expensive.Rehabilitation after ACI takes 12 months, which is inconvenient and not feasible for athletic patients.Newer methods to regenerate cartilage include autologous stem cell transplantation, which may be performed as a single-stage procedure, can have a shorter rehabilitation period and is less expensive than ACI. Longer-term studies of these methods are needed. Cite this article: EFORT Open Rev 2020;5:156-163. DOI: 10.1302/2058-5241.5.190031. © 2020 The author(s). DOI: 10.1302/2058-5241.5.190031 PMCID: PMC7144889