Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 18. Z Orthop Unfall. 2011 Jan;149(1):37-44. doi: 10.1055/s-0030-1250059. Epub 2010 Jul 19. [Regeneration of osteochondral defects in the knee]. [Article in German] Jäger M(1), Bittersohl B, Zilkens C, Herten M, Krauspe R. Author information: (1)Klinik für Orthopädie und Orthopädische Chirurgie, Heinrich-Heine-Universität Düsseldorf. jaeger@med.uni-duesseldorf.de Erratum in Z Orthop Unfall. 2011 Jan;149(1):e1. The application of autologous cells is a standard procedure for the treatment of chondral lesions of the knee. Here, the most frequently used cells are differentiated chondrocytes (autologous chondrocyte implantation, ACI; matrix-induced autologous chondrocyte implantation, MACI). The enzymatic digestion of cartilage tissue by collagenase and isolation of chondrocytes followed by in vitro cultivation are associated with cellular de- and transdifferentiation. To prevent these effects some authors recommend 3D-cultures and culture medium supplementation of defined growth factors and cytokines. Another aim is the reduction of donor site morbidity. Therefore, different progenitor cell types were tested towards their potential for osteochondral regeneration. In particular, MSC derived from bone marrow include several advantages for the treatment of osteochondral defects such as unproblematic sampling, cultivation techniques, and a relatively high degree of biological safety. This review summarises the basic cellular principles as well as clinical results of cell therapeutics for the regeneration of osteochondral defects in the knee. © Georg Thieme Verlag KG Stuttgart · New York. DOI: 10.1055/s-0030-1250059