Chordoma and chondrosarcoma gene profile: implications for immunotherapy.

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Abstract

[Indexed for MEDLINE] 17. J Am Acad Orthop Surg. 2000 Sep-Oct;8(5):292-304. doi: 10.5435/00124635-200009000-00003. Cartilage tumors: evaluation and treatment. Marco RA(1), Gitelis S, Brebach GT, Healey JH. Author information: (1)M.D. Anderson Cancer Center, Houston, USA. The proper treatment of cartilaginous tumors is dependent on the clinicopathologic and radiologic findings. Enchondroma is a benign tumor that is usually asymptomatic and thus should be treated nonoperatively. Symptomatic enchondromas are often treated by intralesional excision. Intramedullary low-grade chondrosarcoma is a malignant tumor that is usually painful. The treatment of low-grade chondrosarcoma may range from intralesional excision with or without adjuvant therapy to wide excision. Although intralesional excisions have a higher bone and joint preservation rate than wide excisions, they may be associated with a higher local recurrence rate. Intermediate- and high-grade chondrosarcomas are treated with wide excisions. The treatment of these cartilaginous lesions should involve a multidisciplinary team including a musculoskeletal surgeon, a radiologist, and a pathologist. DOI: 10.5435/00124635-200009000-00003