The Journal of manual & manipulative therapy | 2021 | Savva C, Karagiannis C, Korakakis V, Efstathiou M
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[Indexed for MEDLINE] Conflict of interest statement: All authors declare that there is not any interest or relationship, financial or otherwise that might be perceived as influencing an author’s objectivity is considered a potential source of conflict of interest. 3. Int J Mol Sci. 2020 Jan 28;21(3):844. doi: 10.3390/ijms21030844. Spectrum of Tendon Pathologies: Triggers, Trails and End-State. Steinmann S(1), Pfeifer CG(1)(2), Brochhausen C(3), Docheva D(1)(4). Author information: (1)Experimental Trauma Surgery, Department of Trauma Surgery, University Medical Center Regensburg, Am Biopark 9, 93053 Regensburg, Germany. (2)Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. (3)Institute of Pathology, University Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. (4)Department of Medical Biology, Medical University-Plovdiv, 15A Vassil Aprilov Blvd., 4002 Plovdiv, Bulgaria. The biggest compartment of the musculoskeletal system is the tendons and ligaments. In particular, tendons are dense tissues connecting muscle to bone that are critical for the integrity, function and locomotion of this system. Due to the increasing age of our society and the overall rise in engagement in extreme and overuse sports, there is a growing prevalence of tendinopathies. Despite the recent advances in tendon research and due to difficult early diagnosis, a multitude of risk factors and vague understanding of the underlying biological mechanisms involved in the progression of tendon injuries, the toolbox of treatment strategies remains limited and non-satisfactory. This review is designed to summarize the current knowledge of triggers, trails and end state of tendinopathies. DOI: 10.3390/ijms21030844 PMCID: PMC7037288
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