Reverse shoulder arthroplasty or nothing for patients with displaced proximal humeral fractures: a randomized controlled trial.

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Abstract

[Indexed for MEDLINE] 10. Int Orthop. 2025 Jul;49(7):1565-1570. doi: 10.1007/s00264-025-06537-w. Epub 2025 Apr 29. Alterations in coagulation profile of patients with periprosthetic joint infections. Saraiva ACM(1), Mozella AP(2)(3), Cobra HAAB(2), Sandes Kimura O(4), Guimarães JAM(5), Defino H(6), Leal AC(7). Author information: (1)Orthopaedic Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. (2)Center for Surgery of Knee, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil. (3)Medical Sciences University, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brasil. (4)Center for Surgery of Hip, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil. (5)Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Avenida Brasil, 500, Rio de Janeiro, RJ, 20940-070, Brasil. (6)Department of Orthopaedics and Anaesthesiology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil. (7)Teaching and Research Division, National Institute of Traumatology and Orthopaedics, Avenida Brasil, 500, Rio de Janeiro, RJ, 20940-070, Brasil. leal.carol@gmail.com. Comment in Int Orthop. 2025 Aug;49(8):2003-2004. doi: 10.1007/s00264-025-06559-4. PURPOSE: This study aims to evaluate changes in the coagulation profile of patients with knee periprosthetic infections (PJI) and determine its diagnostic value in this complication. METHODS: A prospective study was conducted with 112 patients who underwent revision surgery for total knee arthroplasty in a single tertiary hospital between January 2021 and December 2022. RESULTS: 51 patients were diagnosed with PJI. D-dimer (p = 0.001), fibrinogen (p = 0.0007), platelets (0.01), and international normalized ratio (p = 0.01) were significantly higher in patients with PJI. CONCLUSIONS: Patients with PJI display altered coagulation profile. The evaluation of coagulation-related markers has limited value for diagnosing PJI. Further studies are needed to understand the impact of such alterations on patients' outcomes. © 2025. The Author(s). DOI: 10.1007/s00264-025-06537-w PMCID: PMC12179001