Pathophysiology of cervical myelopathy (Review).

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Abstract

Conflict of interest statement: DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests. 4. Semin Neurol. 2021 Jun;41(3):239-246. doi: 10.1055/s-0041-1725144. Epub 2021 May 19. Cervical and Thoracic Spondylotic Myelopathies. Onofrei LV(1), Henrie AM(2). Author information: (1)Department of Neurology, University of Utah, Salt Lake City, UT. (2)Department of Physical Medicine and Rehabilitation, University of Utah, UT. Spondylotic myelopathies are among the most common disorders of the spine, yet the clinical and treatment approach is far from standardized. This article discusses our current understanding of the epidemiology, pathophysiology, clinical assessment, natural history, and treatment options in degenerative myelopathies of the cervical and thoracic spine. We additionally review diagnostic modalities including imaging modalities of the spine and neurophysiological tools such as electromyography/nerve conduction studies, somatosensory-evoked potentials, and motor-evoked potentials. Assessment instruments that can be used for the assessment of myelopathies are reviewed, including the Japanese Orthopedic Association (JOA) score, modified-JOA scale, Nurick scale, nine-hole peg test, and 30-m walking test. We also review common disorders that mimic spondylotic myelopathies, as well as helpful diagnostic clues in differentiating spondylotic and nonspondylotic myelopathies. Thieme. All rights reserved. DOI: 10.1055/s-0041-1725144