[Scapular dyskinesis].

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Abstract

[Indexed for MEDLINE] 5. Biomaterials. 2019 Feb;192:189-198. doi: 10.1016/j.biomaterials.2018.10.037. Epub 2018 Oct 29. Engineered tendon-fibrocartilage-bone composite and bone marrow-derived mesenchymal stem cell sheet augmentation promotes rotator cuff healing in a non-weight-bearing canine model. Liu Q(1), Yu Y(2), Reisdorf RL(2), Qi J(2), Lu CK(2), Berglund LJ(2), Amadio PC(2), Moran SL(2), Steinmann SP(2), An KN(2), Gingery A(2), Zhao C(3). Author information: (1)Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, PR China. (2)Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. (3)Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: zhaoc@mayo.edu. Reducing rotator cuff failure after repair remains a challenge due to suboptimal tendon-to-bone healing. In this study we report a novel biomaterial with engineered tendon-fibrocartilage-bone composite (TFBC) and bone marrow-derived mesenchymal stem cell sheet (BMSCS); this construct was tested for augmentation of rotator cuff repair using a canine non-weight-bearing (NWB) model. A total of 42 mixed-breed dogs were randomly allocated to 3 groups (n = 14 each). Unilateral infraspinatus tendon underwent suture repair only (control); augmentation with engineered TFBC alone (TFBC), or augmentation with engineered TFBC and BMSCS (TFBC + BMSCS). Histomorphometric analysis and biomechanical testing were performed at 6 weeks after surgery. The TFBC + BMSCS augmented repairs demonstrated superior histological scores, greater new fibrocartilage formation and collagen fiber organization at the tendon-bone interface compared with the controls. The ultimate failure load and ultimate stress were 286.80 ± 45.02 N and 4.50 ± 1.11 MPa for TFBC + BMSCS group, 163.20 ± 61.21 N and 2.60 ± 0.97 MPa for control group (TFBC + BMSCS vs control, P = 1.12E-04 and 0.003, respectively), 206.10 ± 60.99 N and 3.20 ± 1.31 MPa for TFBC group (TFBC + BMSCS vs TFBC, P = 0.009 and 0.045, respectively). In conclusion, application of an engineered TFBC and BMSCS can enhance rotator cuff healing in terms of anatomic structure, collagen organization and biomechanical strength in a canine NWB model. Combined TFBC and BMSCS augmentation is a promising strategy for rotator cuff tears and has a high potential impact on clinical practice. Copyright © 2018 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.biomaterials.2018.10.037