High expression of NDRG3 in osteoarthritis patients.

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Abstract

Conflict of interest statement: The authors declare that they have no competing interests. 18. Osteoporos Int. 2022 Jan;33(1):27-37. doi: 10.1007/s00198-021-06070-7. Epub 2021 Aug 12. Changes in bone mineral density in Down syndrome individuals: a systematic review and meta-analysis. Zhang Y(1), Tian Z(2), Ye S(1), Mu Q(3), Wang X(3), Ren S(1), Hou X(1), Yu W(4), Guo J(5). Author information: (1)Department of Pediatric, Peking University People's Hospital, Beijing, 100044, China. (2)Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China. (3)Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, 100044, China. (4)Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, 100044, China. weidongyu@bjmu.edu.cn. (5)Department of Pediatric, Peking University People's Hospital, Beijing, 100044, China. jingzhu.guo@bjmu.edu.cn. Data evaluating changes in bone mineral density (BMD) in Down syndrome (DS) individuals remains controversial. Therefore, we conducted a systematic review and meta-analysis to better understand associations between BMD and DS. A systematic literature search of PubMed, EMBASE, Web of Science, and the Cochrane Library up until 1st January 2021 was conducted. We used the keywords "bone mineral density" and "Down Syndrome." Fifteen studies were included. Overall, our results showed a significant decrease in BMD of total body (TB BMD) [MD =  - 0.18; 95% CI (- 0.23 and - 0.12), P