Updates on Paget's Disease of Bone.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] Conflict of interest statement: CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported. 8. Handb Clin Neurol. 2014;119:529-40. doi: 10.1016/B978-0-7020-4086-3.00034-5. Paget's disease of bone. Gruener G(1), Camacho P(2). Author information: (1)Leischner Institute of Medical Education and Department of Neurology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA. Electronic address: ggruene@lumc.edu. (2)Loyola University Osteoporosis and Metabolic Bone Disease Center, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA. Paget's disease is an osteoclastic-mediated disorder of bone that results in abnormal bone resorption associated with inadequate remodeling that leads to mechanically weakened bone. Demonstrating variable geographic prevalence, it is becoming less frequent and age of onset is lengthening in areas of once high prevalence prior to the institution of effective medical therapies, suggesting its etiology involves both environmental as well as genetic factors. Insights into its pathophysiology are helping to clarify other inherited osteolytic disorders of bone by providing additional insights into related cellular processes. © 2014 Elsevier B.V. All rights reserved. DOI: 10.1016/B978-0-7020-4086-3.00034-5