Emerging local delivery strategies to enhance bone regeneration.

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Abstract

[Indexed for MEDLINE] 15. Annu Rev Biomed Eng. 1999;1:19-46. doi: 10.1146/annurev.bioeng.1.1.19. Tissue engineering: orthopedic applications. Laurencin CT(1), Ambrosio AM, Borden MD, Cooper JA Jr. Author information: (1)Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA. Laurencin@drexel.edu Because of an aging population and increased occurrence of sports-related injuries, musculoskeletal disorders have become one of the major health concerns in the United States. Current treatments, although fairly successful, do not provide the optimum therapy. These treatments typically rely on donor tissues obtained either from the patient or from another source. The former raises the issue of supply, whereas the latter poses the risk of rejection and disease transfer. This has prompted orthopedic surgeons and scientists to look for viable alternatives. In recent years, tissue engineering has gained increasing support as a method to treat orthopedic disorders. Because it uses principles of engineering, biology, and chemistry, tissue engineering may provide a more effective approach to the treatment of musculoskeletal disorders than traditional methods. This chapter presents a review of current methods and new tissue-engineering techniques for the treatment of disorders affecting bone, ligament, and cartilage. DOI: 10.1146/annurev.bioeng.1.1.19