Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Conflict of Interest Disclosures: Dr Bennell reported receiving personal fees from Wolters Kluwer for production of UpToDate knee OA clinical guidelines. Dr Paterson reported receiving grants from the Australian National Health and Medical Research Council (NHMRC) outside the submitted work. Dr Buchbinder report receiving funding from the NHMRC outside the submitted work. Dr Yu reported receiving royalties from Wolters Kluwer for contributions to UpToDate. Mr Connell reported providing PRP injections in clinical practice (Imaging @ Olympic Park). Dr Linklater reported providing PRP injections in clinical practice (Castlereagh Imaging). Dr Hunter reported receiving personal fees for scientific advisory board membership from Biobone, Novartis, Tissuegene, Pfizer, and Lilly. No other disclosures were reported. 2. Periodontol 2000. 2024 Feb;94(1):92-113. doi: 10.1111/prd.12538. Epub 2023 Nov 30. Ten years of injectable platelet-rich fibrin. Miron RJ(1), Gruber R(2), Farshidfar N(3), Sculean A(1), Zhang Y(4). Author information: (1)Department of Periodontology, University of Bern, Bern, Switzerland. (2)Department of Oral Biology, Medical University of Vienna, Vienna, Austria. (3)Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (4)Department of Oral Implantology, University of Wuhan, Wuhan, China. The use of platelet-rich fibrin (PRF) has seen widespread advantages over platelet-rich plasma (PRP) in many fields of medicine. However, until 2014, PRF remained clinically available only in its solid clotted form. Modifications to centrifugation protocols and tube technology have led to the development of a liquid injectable version of PRF (i-PRF). This narrative review takes a look back at the technological developments made throughout the past decade and further elaborates on their future clinical applications. Topics covered include improvements in isolation techniques and protocols, ways to further concentrate i-PRF, and the clinical impact and relevance of cooling i-PRF. Next, various uses of i-PRF are discussed, including its use in regenerative periodontology, implantology, endodontics, temporomandibular joint injections, and orthodontic tooth movement. Furthermore, various indications in medicine are also covered, including its use in sports injuries and osteoarthritis of various joints, treatment of diabetic ulcers/wound care, and facial esthetics and hair regrowth. Finally, future applications are discussed, mainly its use as a drug delivery vehicle for small biomolecules, such as growth factors, antibiotics, exosomes, and other medications that may benefit from the controlled and gradual release of biomolecules over time. © 2023 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd. DOI: 10.1111/prd.12538