Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: One or more of the authors has declared the following potential conflict of interest or source of funding: This study was supported by a grant from the Dutch Arthritis Society. The Dutch Arthritis Society (a nonprofit patient organization) had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The platelet-rich plasma centrifugation system was on loan from Arthrex (Arthrex Medizinische Instrumente GmbH), as is customary under usual care. G.R. has received research support from Arthrex. A.W. has received research support from Arthrex and Biomet. S.M.A.B.-Z. has received consulting fees from Pfizer. G.M.M.J.K. has received research support from Arthrex. J.L.T. has received research support from Arthrex. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. 6. Tech Vasc Interv Radiol. 2020 Dec;23(4):100704. doi: 10.1016/j.tvir.2020.100704. Epub 2020 Oct 6. Biologics. Bowers RL(1), Troyer WD(2), Mason RA(3), Mautner KR(2). Author information: (1)Department of Physical Medicine and Rehabilitation, Emory University School of Medicine, Atlanta, GA; Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA. Electronic address: robert.bowers@emory.edu. (2)Department of Physical Medicine and Rehabilitation, Emory University School of Medicine, Atlanta, GA; Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA. (3)Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA; Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, GA. Biologics are a growing field that has shown immense promise for the treatment of musculoskeletal conditions both in orthopedic sports medicine and interventional pain management. These procedures utilize injection of supraphysiologic levels of platelets and growth factors to invoke the body's own inflammatory cascade to augment the healing of many bony and soft tissue conditions. While many patients improve with conservative care, there is a need to address the gap between those that improve with rehabilitation alone and those who ultimately require operative management. Orthobiologic procedures have the potential to fill this void. The purpose of this review is to summarize the basic science, evidence for use, and post-injection rehabilitation concepts of platelet-rich plasma (PRP) and mesenchymal stromal cells (MSCs) as they pertain to joints, tendons, ligaments, and the spine. Copyright © 2020 Elsevier Inc. All rights reserved. DOI: 10.1016/j.tvir.2020.100704