Evaluation of Platelet Rich Plasma Therapy in Osteoarthritis Of Knee

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Abstract

Background: Knee osteoarthritis (OA) is common entity in adults causing disability and decreased work productivity. Management of early OA is not established showing varied results of conservative and medical treatment. We evaluated the functional outcome of intra-articular injection of platelet rich plasma (PRP) for management of early stages of OA knee. Material and Methods: 30 patients of OA knee, Kellgren type II or III, more than 40 years’ age, were treated with 4 ml of intra-articular autologous PRP injection and were assessed by improvement in functional outcome as seen by WOMAC and VAS score. Results: The mean age was 54.17 ± 8.18 years (range 44 to 78 years). 14 (46.7%) were males and 16 (53.3%) were females. 11 (36.7%) patients had KL grade 2 and 19 (63.3%) patients had KL grade 3 osteoarthritis. The mean pre-procedural WOMAC score of 47.67 ± 6.50 improved to 23.70 ± 5.88, 23.57 ± 5.12 and 25.80 ± 5.69 at one, three and six months after the PRP injection, respectively. The mean pre-procedural VAS score of 5.37 ± 0.85, improved to 1.43 ± 1.04, 1.43 ± 0.63 and 1.73 ± 0.58 at one, three and six months after the PRP injection, respectively. Pain at injection site was seen in 1 (3.3%) patient and 1 (3.3%) patient developed superficial infection. Conclusion: PRP therapy provides pain relief and improves the functional outcome in early stages of Osteoarthritis of Knee.