Cell-based therapy of the elbow: evidence for lateral tendinopathy-a review on current treatments.

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Abstract

[Indexed for MEDLINE] 11. Pain Manag. 2024;14(4):223-233. doi: 10.1080/17581869.2024.2360381. Epub 2024 Jun 14. The concentration of platelets in PRP does not affect pain outcomes in lateral epicondylitis: a systematic review and meta-analysis. Averell N(1)(2), Goodwin B(1)(2), Park S(1), Spicer S(1)(2), Wilson M(1), Mitchell J(1), Martinez N(1), Palhang M(1), Jabon J(1), Jermyn R(1). Author information: (1)Department of Medicine, Rowan University School of Osteopathic Medicine, Stratford, NJ 08043, USA. (2)Futures Forward Research Institute, Toms River, NJ 08753, USA. Aim: To investigate the analyze the relationship between concentration platelet-dose in platelet-rich plasma (PRP) injections and improvements in pain when treating lateral epicondylitis. Methods: A systematic review was conducted into five medical databases, exploring the difference in pain outcomes based on concentration of PRP. Results: Initial querying of the databases yielded 1408 articles with 20 articles ultimately included. There was no statistical significance between effect sizes of the two treatment groups (high and low platelet concentration; p = 0.976). Conclusion: Both large and small concentrations of platelets depict significant reduction in pain, however, between subgroups there was no significance. It can thus be concluded that concentration of platelets in PRP does not impact overall pain relief. Plain Language Summary: [Box: see text]. DOI: 10.1080/17581869.2024.2360381 PMCID: PMC11229443