OARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis.

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Abstract

[Indexed for MEDLINE] 6. Nat Rev Rheumatol. 2019 Jul;15(7):438-448. doi: 10.1038/s41584-019-0237-3. Epub 2019 Jun 14. Establishing outcome measures in early knee osteoarthritis. Emery CA(1), Whittaker JL(2), Mahmoudian A(3), Lohmander LS(4), Roos EM(5), Bennell KL(6), Toomey CM(7), Reimer RA(8), Thompson D(9), Ronsky JL(10), Kuntze G(7), Lloyd DG(11), Andriacchi T(12)(13), Englund M(14), Kraus VB(15), Losina E(16), Bierma-Zeinstra S(17), Runhaar J(18), Peat G(19), Luyten FP(3), Snyder-Mackler L(20), Risberg MA(21), Mobasheri A(22)(23), Guermazi A(24), Hunter DJ(25), Arden NK(26). Author information: (1)Sport Injury Prevention Research Centre, Faculty of Kinesiology and Alberta Children's Hospital Research Institute and McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. caemery@ucalgary.ca. (2)Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada. (3)Division of Rheumatology, Skeletal Biology & Engineering Research Center, University Hospitals KU Leuven, Leuven, Belgium. (4)Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden. (5)Department of Sports and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. (6)Centre for Health, Exercise and Sports Medicine, University of Melbourne, Melbourne, Victoria, Australia. (7)Sport Injury Prevention Research Centre, Faculty of Kinesiology and Alberta Children's Hospital Research Institute and McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. (8)Faculty of Kinesiology and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada. (9)Department for Health, University of Bath, Bath, UK. (10)Schulich School of Engineering, Faculty of Kinesiology and McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. (11)Gold Coast Orthopaedic Research, Engineering and Education (GCORE), Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia. (12)Department of Mechanical Engineering and Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA. (13)Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA. (14)Clinical Epidemiology Unit, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden. (15)Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA. (16)The Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Harvard Medical School and Boston University School of Public Health, Boston, MA, USA. (17)Department of Orthopaedics, Erasmus MC - University Medical Center Rotterdam, Rotterdam, Netherlands. (18)Department of General Practice, Erasmus MC - University Medical Center Rotterdam, Rotterdam, Netherlands. (19)Research Institute for Primary Care & Health Sciences, Keele University, Staffordshire, UK. (20)Departments of Physical Therapy and Biomedical Engineering, STAR Health, University of Delaware, Newark, DE, USA. (21)Norwegian Research Center for Active Rehabilitation, Department of Sports Medicine, Norwegian School Sport Sciences and Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway. (22)Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. (23)Queen's Medical Centre, Nottingham, UK. (24)Boston University School of Medicine, Boston, MA, USA. (25)Institute of Bone and Joint Research, Kolling Institute, University of Sydney and Rheumatology Department, Royal North Shore Hospital, Sydney, New South Wales, Australia. (26)Oxford University, Oxford, UK. The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting. DOI: 10.1038/s41584-019-0237-3