Biologic Augmentation of Rotator Cuff Repair: Current Concepts Review.

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Abstract

[Indexed for MEDLINE] 14. Colloids Surf B Biointerfaces. 2017 Sep 1;157:407-416. doi: 10.1016/j.colsurfb.2017.06.004. Epub 2017 Jun 6. Biomaterials based strategies for rotator cuff repair. Zhao S(1), Su W(1), Shah V(2), Hobson D(2), Yildirimer L(3), Yeung KWK(4), Zhao J(5), Cui W(6), Zhao X(7). Author information: (1)Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China. (2)Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China. (3)Barnet General Hospital, Royal Free NHS Trust Hospital, Wellhouse Lane, Barnet EN5 3DJ, London, UK. (4)Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China. (5)Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China. Electronic address: zhaojinzhongdoctor@163.com. (6)Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Rd., Suzhou, Jiangsu 215006, China. Electronic address: wgcui80@hotmail.com. (7)Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China. Electronic address: xin.zhao@polyu.edu.hk. Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects. In this review, we first give a brief introduction of the anatomy of the rotator cuff and then discuss various design strategies to augment rotator cuff repair. Furthermore, we highlight current biomaterials used for repair and their clinical applications as well as the limitations in the literature. We conclude this article with challenges and future directions in designing more advanced biomaterials for augmentation of rotator cuff repair. Copyright © 2017 Elsevier B.V. All rights reserved. DOI: 10.1016/j.colsurfb.2017.06.004