Cryptococcal infection of the femur misdiagnosed as a primary bone tumor: A case report and literature review.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of conflicting interestsNone declared. 7. Quant Imaging Med Surg. 2022 Aug;12(8):4304-4315. doi: 10.21037/qims-22-108. Cystic lesions of the humeral head on magnetic resonance imaging: a pictorial review. Mangi MD(1), Zadow S(2)(3), Lim W(2)(4). Author information: (1)Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia. (2)Dr Jones & Partners Medical Imaging, Adelaide, Australia. (3)Department of Medical Imaging, Flinders Medical Centre, Adelaide, Australia. (4)Department of Radiology, Royal Adelaide Hospital, Adelaide, Australia. Cystic lesions of the humeral head are commonly encountered on routine shoulder magnetic resonance imaging (MRI). Differential diagnoses include degenerative lesions, calcific tendinitis with osseous involvement, perianchor cysts, abscesses and less often, tumours. Degenerative lesions, including subcortical and subchondral cysts, are the most commonly encountered. These may be associated with rotator cuff disease and degenerative joint diseases or considered part of ageing depending on the location of the cystic lesions. For instance, cysts of the bare area of the humeral head are considered benign age-related entities, whereas cysts of the greater or lesser tuberosity may herald rotator cuff disease. Infectious lesions, particularly osteomyelitis and intraosseous (Brodie's) abscesses, are intramedullary in location and should be suspected in the context of clinical features such as fever and radiological features such as the penumbra sign. Perianchor cysts are postoperative lesions associated with the use of suture anchors in surgeries such as rotator cuff tear repairs. They generally self-resolve over 18 to 24 months. On MRI, the distribution, morphology, and signal characteristics can help point towards a specific diagnosis. The patient's demographic, clinical presentation, and past surgical history can be discriminatory. Knowledge of different cystic lesions in the humeral head and underlying aetiology can be useful in helping the radiologist develop a more thorough search pattern for associated conditions. Determining the underlying cause of cysts can have important implications on management, such as when differentiating perianchor cysts from infection. This pictorial review outlines the differential diagnoses of humeral head cysts on MRI and provides a diagnostic approach for the radiologist. 2022 Quantitative Imaging in Medicine and Surgery. All rights reserved. DOI: 10.21037/qims-22-108 PMCID: PMC9338365