Ultrasound-guided injection of platelet-rich plasma for tendinopathies: a systematic review and meta-analysis.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The Authors declare no conflicts of interest. 2. BMC Musculoskelet Disord. 2025 Apr 8;26(1):339. doi: 10.1186/s12891-025-08566-3. Platelet-rich plasma and corticosteroid injection for tendinopathy: a systematic review and meta-analysis. Ye Z(1)(2), Yuan Y(1), Kuang G(2), Qiu L(1)(2), Tan X(3), Wen Z(1)(2), Lu M(4). Author information: (1)Hunan University of Chinese Medicine, Changsha, 410208, China. (2)The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China. (3)Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, 410006, China. (4)The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China. lumin6563@163.com. OBJECTIVE: In this systematic review and meta-analysis, we evaluated and compared the efficacy and safety of platelet-rich plasma injection into corticosteroid injection in the treatment of tendinopathy. METHODS: We searched PUBMED, EMBASE, Cochrane Library, SCOPUS, and Web of Science to identify randomized controlled trials on the PRP injection versus CS injection in treatment of tendinopathy.The meta-analysis was performed using the Revman 5.4 software. RESULT: We found 27 RCT studies with a total of 1779 patients enrolled. 8 rotator cuff injuries, 7 humeral external epicondylitis, 10 plantar fasciitis, and 2 tenosynovitis. The results of the meta-analysis showed that there were no significant group differences in the results of patients with rotator cuff injury comparing the pain visual analog scale score and functional measures at 1 month after receiving injection treatment. After three months of receiving PRP treatment, the VAS scores showed greater improvement compared to the CS group(OR = -1.64,95%CI [-2.97,-0.31],P = 0.02), while there was no statistically significant difference in shoulder joint function between the two groups at the 3-6 month post-treatment mark. Patients with plantar fasciitis showed no significant differences in VAS and AOFAS scores after receiving PRP or CS injections at 1 and 3 months. However, at the 6-month mark, the PRP group demonstrated significantly better VAS and AOFAS scores compared to the CS group(OR = -1.41,95%CI [-1.88,-0.44],P