Precision electronic medicine in the brain.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Competing financial interests S.R.P. has no competing financial interests. C.M.L. is a co- inventor on patents and patent applications relating to the article that have been filed by the authors’ institution (Harvard University) as follows: ‘Scaffolds comprising nanoelectronic components, tissues, and other applications’, inventors C.M.L., J. Liu, B. Tian, T. Dvir, R. S. Langer and D. S. Kohane; US9,457,128 (issued); describes nanoscale transistors for cell recording. ‘Systems and methods for injectable devices’, inventors C.M.L., J. Liu, Z. Cheng, G.H., T.-M. Fu and T. Zhou; 61/975,601 (pending), PCT/US2015/024252 (pending) and 15/301,792 (pending); describes injectable mesh electronics. ‘Techniques and systems for injection and/or connection of electrical devices’, inventors C.M.L., G.H., T.-M. Fu and J. Huang; 62/209,255 (pending), PCT/US2016/045587 (issued) and 15/749,617 (pending); describes injection method of mesh electronics. The authors are not involved in efforts related to commercialization of this intellectual property 15. Digit Amputation. Zhang L(1), Azmat CE(2), Buckley CJ(3). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2023 Jan 30. Author information: (1)Derriford Hospital (2)University of Child Health Sciences, The Children Hospital, Lahore (3)Baylor Scott & White Digital amputation is often associated with traumatic injuries but is also seen within the elective surgery setting, such as cancer resection and management of chronic conditions such as Dupuytrens contractures or peripheral vascular disease. It is also seen as a consequence of severe sepsis, although this often results in auto-amputation.  In the traumatic setting, the primary objective of management is to salvage the amputated finger to restore function, especially if the dominant hand is affected. However, this is not always possible, as there are many factors to consider. These factors include the time from injury, mechanism of injury, and degree of contamination . In the elective setting, determinants for the level of amputation include various factors, such as oncological clearance, symptom relief, and function preservation; however, for the purpose of this paper, the primary focus will be on a traumatic finger amputation. The basic goal in the treatment of digit amputations (especially upper limb) includes: Preservation of functional length. Durable coverage. Preservation of useful sensibility. Prevention of symptomatic neuromas. Prevention of adjacent joint contractures. Early return to work. Early prosthetic fitting. Copyright © 2026, StatPearls Publishing LLC.