KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis.

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Abstract

[Indexed for MEDLINE] 4. Knee Surg Relat Res. 2022 Jun 20;34(1):30. doi: 10.1186/s43019-022-00158-y. Bone loss in aseptic revision total knee arthroplasty: management and outcomes. Bieganowski T(1), Buchalter DB(1), Singh V(1), Mercuri JJ(2), Aggarwal VK(1), Rozell JC(1), Schwarzkopf R(3). Author information: (1)Division of Adult Reconstruction, Department of Orthopedic Surgery, NYU Langone Health, 301 East 17th Street, New York, NY, 10003, USA. (2)Department of Orthopedic Surgery, Geisinger Health, Scranton, PA, USA. (3)Division of Adult Reconstruction, Department of Orthopedic Surgery, NYU Langone Health, 301 East 17th Street, New York, NY, 10003, USA. Ran.Schwarzkopf@nyulangone.org. BACKGROUND: Although several techniques and implants have been developed to address bone loss in revision total knee arthroplasty (rTKA), management of these defects remains challenging. This review article discusses the indications and management options of bone loss following total knee arthroplasty based on preoperative workup and intraoperative findings. MAIN TEXT: Various imaging modalities are available that can be augmented with intraoperative examination to provide a clear classification of a bony defect. For this reason, the Anderson Orthopaedic Research Institute (AORI) classification is frequently used to guide treatment. The AORI provides a reliable system by which surgeons can classify lesions based on their size and involvement of surrounding structures. AORI type I defects are managed with cement with or without screws as well as impaction bone grafting. For AORI type IIA lesions, wedge or block augmentation is available. For large defects encompassing AORI type IIB and type III defects, bulk allografts, cones, sleeves, and megaprostheses can be used in conjunction with intramedullary stems. CONCLUSIONS: Treatment of bone loss in rTKA continues to evolve as different techniques and approaches have been validated through short- and mid-term follow-up. Extensive preoperative planning with imaging, accurate intraoperative evaluation of the bone loss, and comprehensive understanding of all the implant options available for the bone loss are paramount to success. © 2022. The Author(s). DOI: 10.1186/s43019-022-00158-y PMCID: PMC9208118