Osteobiologics.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] 7. Macromol Biosci. 2021 Apr;21(4):e2000365. doi: 10.1002/mabi.202000365. Epub 2021 Feb 22. Biomaterial Properties Modulating Bone Regeneration. Zhu Y(1), Goh C(2)(3), Shrestha A(1)(4). Author information: (1)Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada. (2)Department of Chemistry, University of Toronto, 80 George Street, Toronto, Ontario, M5S 3H6, Canada. (3)Department of Materials Science and Engineering, University of Toronto, 84 College Street, Suite 140, Toronto, Ontario, M5S 3E4, Canada. (4)Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. Biomaterial scaffolds have been gaining momentum in the past several decades for their potential applications in the area of tissue engineering. They function as three-dimensional porous constructs to temporarily support the attachment of cells, subsequently influencing cell behaviors such as proliferation and differentiation to repair or regenerate defective tissues. In addition, scaffolds can also serve as delivery vehicles to achieve sustained release of encapsulated growth factors or therapeutic agents to further modulate the regeneration process. Given the limitations of current bone grafts used clinically in bone repair, alternatives such as biomaterial scaffolds have emerged as potential bone graft substitutes. This review summarizes how physicochemical properties of biomaterial scaffolds can influence cell behavior and its downstream effect, particularly in its application to bone regeneration. © 2021 Wiley-VCH GmbH. DOI: 10.1002/mabi.202000365