Nanotechnology-based biomaterials for orthopaedic applications: Recent advances and future prospects.

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Abstract

[Indexed for MEDLINE] 7. J Orthop Surg Res. 2025 Oct 28;20(1):927. doi: 10.1186/s13018-025-06279-w. Current developments in orthopaedic implant technology. Misir A(1)(2). Author information: (1)Department of Orthopedics and Traumatology, Bahçeşehir University Faculty of Medicine, Istanbul, Turkey. misirabdulhamitmd@gmail.com. (2)Medicalpark Goztepe Hospital, Department of Orthopedics and Traumatology, Bahcesehir University Faculty of Medicine, Merdivenkoy, E-5 uzeri, Nisan Sk. No:17, Istanbul, 34732, Kadikoy, Turkey. misirabdulhamitmd@gmail.com. Orthopaedic implants have significantly improved the treatment of musculoskeletal injuries and degenerative diseases, restoring function and alleviating pain. However, long-term implant success remains challenging due to loosening, wear, and infections. Recent advancements in materials science, bioengineering, and digital technologies are driving innovations in orthopaedic implants, enhancing their performance and patient outcomes. New biomaterials, such as advanced metal alloys, polymers, ceramics, and nanocomposites, offer superior biocompatibility and mechanical durability, minimizing adverse reactions. Additive manufacturing (3D printing) allows the creation of patient-specific implants with porous architectures closely resembling natural bone, enhancing osseointegration. Additionally, surface engineering techniques, including bioactive coatings for improved bone bonding and antimicrobial layers for infection prevention, address persistent issues at the implant-tissue interface. The emergence of "smart" implants equipped with sensors and wireless connectivity enables real-time monitoring of biomechanical parameters, paving the way for personalized, data-driven orthopaedic care. This review summarizes significant developments in orthopaedic implant technology from 2020 to 2025, highlighting advances in materials, design, and functionality. We discuss how these innovations address traditional challenges and examine remaining hurdles to clinical application. Future directions, such as biodegradable implants that eliminate secondary surgeries and AI-assisted implant design, are also explored. Collectively, these breakthroughs promise a new era in orthopaedic treatments, marked by enhanced implant longevity, functionality, and patient quality of life. © 2025. The Author(s). DOI: 10.1186/s13018-025-06279-w PMCID: PMC12560316