Current solutions for the treatment of chronic articular cartilage defects in the knee.

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Abstract

Conflict of interest statement: ICMJE Conflict of interest statement: GB reports that he is the Scientific Editor for EFORT Open Reviews, outside the submitted work. The other authors report no conflict of interest relevant to this work. 16. Cartilage. 2021 Dec;13(1_suppl):1298S-1305S. doi: 10.1177/19476035211030991. Epub 2021 Jul 21. Etiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation. Mestriner AB(1)(2), Ackermann J(3)(4), Merkely G(2)(5), Galvão PHSAF(1), Ambra LFM(1), Gomoll AH(6). Author information: (1)Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil. (2)Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical Center, Boston, MA, USA. (3)Sports Medicine Center, Massachusetts General Hospital, Boston, MA, USA. (4)Balgrist University Hospital, Zurich, Switzerland. (5)Department of Traumatology, Semmelweis University, Budapest, Hungary. (6)Hospital for Special Surgery, New York, NY, USA. OBJECTIVE: To determine the relationship between cartilage lesion etiology and clinical outcomes after second-generation autologous chondrocyte implantation (ACI) in the patellofemoral joint (PFJ) with a minimum of 2 years' follow-up. METHODS: A retrospective review of all patients that underwent ACI in the PFJ by a single surgeon was performed. Seventy-two patients with a mean follow-up of 4.2 ± 2.0 years were enrolled in this study and were stratified into 3 groups based on the etiology of PFJ cartilage lesions: patellar dislocation (group 1; n = 23); nontraumatic lesions, including chondromalacia, osteochondritis dissecans, and degenerative defects (group 2; n = 28); and other posttraumatic lesions besides patellar dislocations (group 3; n = 21). Patient's mean age was 29.6 ± 8.7 years. Patients in group 1 were significantly younger (25.4 ± 7.9 years) than group 2 (31.7 ± 9.6 years; P = 0.025) and group 3 (31.5 ± 6.6 years; P = 0.05). Body mass index averaged 26.2 ± 4.3 kg/m2, with a significant difference between group 1 (24.4 ± 3.2 kg/m2) and group 3 (28.7 ± 4.5 kg/m2; P = 0.005). A clinical comparison was established between groups based on patient-reported outcome measures (PROMs) and failure rates. RESULTS: Neither pre- nor postoperative PROMs differed between groups (P > 0.05). No difference was seen in survivorship between groups (95.7% vs. 82.2% vs. 90.5%, P > 0.05). CONCLUSION: Cartilage lesion etiology did not influence clinical outcome in this retrospective study after second generation ACI in the PFJ. LEVEL OF EVIDENCE: Level III, retrospective comparative study. DOI: 10.1177/19476035211030991 PMCID: PMC8808922