Growth plate mechanics and mechanobiology. A survey of present understanding.

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Abstract

[Indexed for MEDLINE] 6. Int J Mol Sci. 2022 May 25;23(11):5916. doi: 10.3390/ijms23115916. Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide. Rintz E(1)(2), Węgrzyn G(1), Fujii T(3), Tomatsu S(2)(4). Author information: (1)Department of Molecular Biology, Faculty of Biology, University of Gdansk, 80-308 Gdansk, Poland. (2)Skeletal Dysplasia Research Lab, Nemours Children's Health, 1600 Rockland Rd., Wilmington, DE 19899, USA. (3)Department of Diabetes, Endocrinology, and Nutrition, Kyoto University Hospital, Kyoto 606-8507, Japan. (4)Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107, USA. The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative, hypertrophic to calcified zones. Natriuretic peptides (NPTs) are peptide hormones with multiple functions, including regulation of blood pressure, water-mineral balance, and many metabolic processes. NPTs secreted from the heart activate different tissues and organs, working in a paracrine or autocrine manner. One of the natriuretic peptides, C-type natriuretic peptide-, induces bone growth through several mechanisms. This review will summarize the knowledge, including the newest discoveries, of the mechanism of CNP activation in bone growth. DOI: 10.3390/ijms23115916 PMCID: PMC9180634