Rehabilitation after autologous chondrocyte implantation in athletes.

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Abstract

[Indexed for MEDLINE] 2. Bone. 2022 Dec;165:116544. doi: 10.1016/j.bone.2022.116544. Epub 2022 Sep 6. Implant system for large osteochondral defects. Lohfeld S(1), Curtin W(2), McHugh PE(3). Author information: (1)Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA; Biomedical Engineering, School of Engineering, National University of Ireland Galway, Ireland. Electronic address: lohfelds@umkc.edu. (2)Galway University Hospitals, Galway, Ireland. (3)Biomedical Engineering, School of Engineering, National University of Ireland Galway, Ireland. Electronic address: peter.mchugh@nuigalway.ie. Issues with current treatments for osteochondral defects such as mosaicplasty and autologous chondrocyte implantation (ACI) are lack of donor material, problems associated with donor sites, necessity of second surgical intervention and cell expansion, difficult site preparation and implant fitting to match the surrounding tissue. This study presents the development of a patient specific implant system for focal osteochondral defects that addresses these issues. Using computer aided design and manufacturing techniques, computed tomography scans are utilized to design the implant and templates that facilitate site preparation to allow for precise and easy implantation of the designed perfectly fitting tissue replacement. Functionality of the system and accurate restoration of a defect is demonstrated by digital before/after comparison and with a prototype. With the presented implantation system larger defects in curved joint surfaces can be restored to an optimal shape in an easier procedure than for instance mosaicplasty. The proposed system potentially allows for later replacement of worn implants. Copyright © 2022 Elsevier Inc. All rights reserved. DOI: 10.1016/j.bone.2022.116544