Tenosynovial giant cell tumours of the foot and ankle: a retrospective single centre experience with surgical treatment of 34 cases.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: Approval of local ethics committee (TU Munich) was obtained (no. 2023-103-S-KH). All patients signed an informed consent form. Consent for publication: All authors agreed to publish. Competing interests: The authors declare no competing interests. 9. Cureus. 2024 Mar 15;16(3):e56215. doi: 10.7759/cureus.56215. eCollection 2024 Mar. Giant Cell Tumor in Tarsal Midfoot Bones: A Case Report. Abed Alharbi W(1), Mohammed Alshareef H(2), Hennawi YB(3), Munshi AA(3), Khalid Alzahrani A(1). Author information: (1)Department of Orthopedics, King Fahad Armed Forces Hospital, Jeddah, SAU. (2)Department of Orthopedic Surgery, King Fahad Armed Forces Hospital, Jeddah, SAU. (3)College of Medicine, Umm Al-Qura University, Makkah, SAU. Diffuse tenosynovial giant cell tumor (D-TGCT), previously known as pigmented villonodular synovitis (PVNS), is a benign, aggressive, and distracting proliferative synovial lesion. D-TGCT is commonly seen in large joints such as the knee and hip. We present the case of a 57-year-old female who initially presented with swelling on the left midfoot that increased over four years. Clinically, a ganglion was suspected on the left midfoot and an MRI showed a heterogeneous lobulated soft tissue mass on the superior aspect of the tarsal midfoot measuring 5.8 x 2.4 x 4.2 cm. The mass causing remodeling and bony erosion was more appreciated at the medial aspect of the talus bone and extended to the sinus tarsi and talocalcaneal joint space. Surgical excision of the mass was performed, and pathology reports found lobulated soft tissue lesions composed of mononuclear cells, multinucleated giant cells, sheets of foamy macrophages, inflammatory cells, and hemosiderin-laden macrophages. This case represents D-TGCT without atypia or malignancy based on the findings. Copyright © 2024, Abed Alharbi et al. DOI: 10.7759/cureus.56215 PMCID: PMC11017238