Pexidartinib in the Management of Advanced Tenosynovial Giant Cell Tumor: Focus on Patient Selection and Special Considerations.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

Conflict of interest statement: Anna Vaynrub and Max Vaynrub report no conflicts of interest in this work. John Healey has served as a consultant for Daiichi Sankyo and Stryker Consultant, as a trustee for the Musculoskeletal Transplant Foundation, and as a symposium editor for Clinical Orthopaedics and Related Research. William Tap reports personal fees from Eli Lilly, EMD Serono, Mundipharma, C4 Therapeutics, Daiichi Sankyo, Blueprint, Agios Pharmaceuticals, NanoCarrier, Deciphera, Adcendo, Ayala Pharmaceuticals, Kowa, Servier, Bayer Pharmaceuticals, Epizyme, Cogent, and Medpacto outside the current article. In addition, Dr. Tap has a patent (Companion diagnostic for CDK4 inhibitors - 14/854,329) pending to Memorial Sloan Kettering Cancer Center/Sloan Kettering Institute (SKCC/SKI), and a patent (Enigma and CDH18 as companion diagnostics for CDK4 inhibition – SKI2016-021-03) pending to MSKCC/SKI; is a member of the scientific advisory boards of Certis Oncology Solutions and Innova Therapeutics, and owns stock in Atropos Therapeutics and Innova Therapeutics. 11. Ortop Traumatol Rehabil. 2017 Jan 26;19(1):79-88. doi: 10.5604/15093492.1235281. Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. Kokoszka P(1), Woźniak W(1), Łapaj Ł(1), Kruczyński J(1). Author information: (1)Department of General Orthopedics, Orthopedic Oncology and Traumatology, Poznań University of Medical Sciences, Poland. Pigmented villonodular synovitis (PVNS) as well as tenosynovial giant cell tumor (TGCT) are both diagnosed and described in two forms, namely a localized and diffuse type. They form a diverse group of proliferative lesions in articular synovium and tendon sheaths. The inconsistent terminology impedes communication between patients, orthopedic surgeons, radiologists and pathologists, leading to misunderstandings and delaying treatment. In this paper, we present three cases of PVNS/TGCT (involving the fourth toe extensor tendon sheath, hip joint after resurfacing and flexor hallucis longus tendon sheath) together with suggestions regarding the unification of the terminology as well as diagnosis and treatment. DOI: 10.5604/15093492.1235281