Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable CONSENT FOR PUBLICATION: Not applicable COMPETING INTERESTS: Jo Caers received honoraria from Amgen, Celgene, and Janssen-Cilag and research grants from Celgene. Elena Zamagni received honoraria from Janssen-Cilag, Celgene, BMS, and Amgen. Niels Abdilgaard received research grants from Takeda, Celgene, and Amgen and honoraria from Takeda, Celgene, and Janssen-Cilag. Xavier Leleu received honoraria from Janssen-Cilag, Celgene, Novartis, Sanofi, Amgen, Takeda, Pierre Fabre, Gilead, BMS, and Merck. Laura Rosinol received honoraria from Janssen, Celgene, Amgen, and Takeda. The other authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 9. ORL J Otorhinolaryngol Relat Spec. 2023;85(4):231-237. doi: 10.1159/000530946. Epub 2023 Jun 26. Plasmacytoma of the Head and Neck: Case Series and Review of the Literature. Lamb MM(1), Zeatoun A(2), Stack TJ(2), Kim S(2), Albastoni S(3), Singer B(3), Klatt-Cromwell C(2), Senior BA(2), Kimple AJ(2), Thorp BD(2). Author information: (1)Department of Otolaryngology/Head and Neck Surgery at the University of North Carolina, Chapel Hill, North Carolina, USA, m_meyer0208@email.campbell.edu. (2)Department of Otolaryngology/Head and Neck Surgery at the University of North Carolina, Chapel Hill, North Carolina, USA. (3)Department of Pathology & Laboratory Medicine at the University of North Carolina, Chapel Hill, North Carolina, USA. Solitary plasmacytoma is a rare neoplasm characterized by localized proliferation of monoclonal plasma cells and is classified as solitary bone or solitary extramedullary plasmacytoma. Here, we present two rare cases of plasmacytoma of the head and neck. The first is a 78-year-old male who presented with a 3-month history of epistaxis and progressive obstruction of the right nasal passage. Computerized tomography (CT) imaging revealed a mass in the right nasal cavity with destruction to the maxillary sinus. An excisional biopsy was performed revealing anaplastic plasmacytoma. The second is a 64-year-old male with a past medical history significant for prostate cancer who presented with a 2-month history of left ear pain and progressive non-tender temporal swelling. A PET/CT revealed a highly avid, destructive, and lytic left temporal mass with no other evidence of distant disease. A left temporal craniectomy and infratemporal fossa dissection revealed plasma cell dyscrasia with monoclonal lambda in situ hybridization. Although plasmacytomas are uncommon tumors of the head and neck, they may mimic other entities that require different treatment. Prompt and accurate diagnosis is critical for appropriate therapeutic decisions and prognosis. © 2023 S. Karger AG, Basel. DOI: 10.1159/000530946