Advantages of Pressurized-Spray Cryosurgery in Giant Cell Tumors of the Bone.

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Abstract

Conflict of interest statement: No conflict of interest was declared by the authors. 4. Zhonghua Yi Xue Za Zhi. 2014 Dec 23;94(47):3778-83. [Meta-analysis of risk factors of recurrence in patients with giant cell tumor on extremities]. [Article in Chinese] Li R(1), Hu Y(2). Author information: (1)Department of Orthopedics, First Hospital, Jiamusi University, Heilongjiang 154002, China. (2)Department of Bone Tumor, Tianjin Hospital, Tianjin 300210, China. Email: yongchenghu@126.com. OBJECTIVE: To explore the risk factors of giant cell tumor on extremities for patients with postoperative recurrence. METHODS: The literature reports published before June 2014 were searched in the electronic databases of CBM, CNKI, PUBNED, MEDLINE and EMBASE. Meta-analysis was performed by software Review Manager (Version 5.3). The odds ratios (OR) of gender, age, tumor site, Campanacci Classification, pathological fracture, selection of treatment and soft tissue invasion were analyzed with heterogeneity test. Publication bias were tested by funnel plot and fail-safe number.Sensitivity analysis was performed to assess the stability. RESULTS: A total of 15 case-control studies were identified. Age, location and type of surgery were associated with tumor recurrence. The combined OR (95%CI) was 1.83 (1.04-3.24) P = 0.04 for aged 40 years, 1.60 (1.06-2.42) P = 0.02 for distal radius, 0.35 (0.14-0.90) P = 0.03 for proximal humerus, 3.64 (1.88-7.04) P = 0.0001 for curettage,0.56 (0.35-0.91) P = 0.02 for curettage with PMMA, 1.79 (1.11-2.88) P = 0.02 for curettage with bone graft and adjuvant and 0.29 (0.12-0.66) P = 0.003 for resection respectively. There were not significant relationship between tumor recurrence and gender, tumor location (distal femur, proximal femur, distal tibia, proximal tibia), Jaffe staging, Campanacci classification,Enneking classification, pathological fracture, soft tissue invasion, extensive curettage, curettage with bone graft, curettage with polymethylmethacrylate and adjuvant (P > 0.05). CONCLUSION: Youth (aged 40 years), proximal tibia, curettage with PMMA and resection appear to have lower risks for tumor recurrence.