Giant cell tumour of bone. A surgical approach to grade III tumours.

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Abstract

[Indexed for MEDLINE] 6. BMC Musculoskelet Disord. 2022 Dec 5;23(1):1061. doi: 10.1186/s12891-022-06005-1. Mid-term results of giant cell tumours with pathologic fractures around the knee: a multicentre retrospective study. Zhao L(1), Chen J(2), Hu Y(3), Ye Z(4), Tao K(5). Author information: (1)Department of Joint Surgery, Ningbo No.6 Hospital, No. 1059 East Zhongshan Road, Ningbo, 315040, Zhejiang Province, China. (2)Langfang Health Vocational College, Siguang South Road, Langfang, 065000, Hebei Province, China. (3)Department of Orthopaedic Oncology, Tianjin Hospital, No. 406 Jiefang South Road, Tianjin, 300211, China. (4)Department of Orthopaedic Oncology, The Second Affiliated Hospital of Zhejiang University, No. 1511 Jianghong Road, Hangzhou, 315040, Zhejiang Province, China. (5)Department of Joint Surgery, Ningbo No.6 Hospital, No. 1059 East Zhongshan Road, Ningbo, 315040, Zhejiang Province, China. taokun_714@126.com. OBJECTIVE: The aims of this work are to present a classification of "complex fracture" and "simple fracture", to compare their features, treatments and prognosis in patients with giant cell tumour with pathologic fractures around the knee, and to determine the best surgical method for patients who have giant cell tumour around the knee with different degrees of fracture. METHODS: Data from 130 patients with pathologic fractures from giant cell tumour around the knee who underwent surgical treatment from March 2000 to November 2015 at 6 institutes around China were collected and analysed. A multicentric study design was used to explore the epidemiological features and to compare differences in the surgical procedures and prognosis of the two fracture groups. The mean age at diagnosis was 37.1 years old (range, 13-77 years). The median follow-up was 126.5 months, ranging from 68 to 370 months. RESULTS: The general clinical and imaging features of the groups of patients with simple and complex fractures, namely, sex, age, the lesion site, living or working environment, eccentric growth patterns, Campanacci grading system, and duration of symptoms before treatment, showed varying degrees of differences, but with no statistical significance (p > 0.05). The incidence rate of surrounding soft tissue mass was 35.2% (32/91) in the group with simple fractures, whereas it was 87.2% (34/39) in the group with complex fractures, which showed a significant difference (p