Mid-term results of giant cell tumours with pathologic fractures around the knee: a multicentre retrospective study.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflict of interest. 18. J Orthop Sci. 2022 May;27(3):681-688. doi: 10.1016/j.jos.2021.02.001. Epub 2021 Mar 5. Complications of surgery for giant cell tumor of bone in the extremities: Incidence, risk factors, management modality, and impact on functional and oncological outcomes. Morii T(1), Asano N(2), Nakayama R(2), Kikuta K(3), Susa M(4), Horiuchi K(4), Watanabe I(5), Anazawa U(5), Suzuki Y(6), Nishimoto K(7), Takeuchi K(8), Morioka H(9). Author information: (1)Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611 Japan. Electronic address: t-morii@gb3.so-net.ne.jp. (2)Department of Orthopaedic Surgery, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. (3)Department of Orthopaedic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, Tochigi, 320-0834, Japan. (4)Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042, Japan. (5)Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan. (6)Department of Orthopaedic Surgery, Tachikawa Hospital, 4-2-22 Nishiki-cho, Tachikawa, Tokyo, 190-8531, Japan. (7)Department of Orthopaedic Surgery, Kawasaki Municipal Ida Hospital, 2-27-1 Ida, Nakahara-ku, Kawasaki, Kanagawa, 211-0035, Japan. (8)Department of Orthopaedic Surgery, Saiseikai Yokohamashi Nanbu Hospital, 3-2-10, Konandai Konan-ku, Yokohama, Kanagawa, 234-0054, Japan. (9)Department of Orthopaedic Surgery, National Hospital Organization, Tokyo Medical Center., 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan. BACKGROUND: Due to the wide variations in location, size, local invasiveness, and treatment options, the complications associated with surgery for giant cell tumor of bone have been sporadically reported. For quality assessment, fundamental data based on large-scale surveys of complications under a universal evaluation system is needed. The Dindo-Clavien classification is an evaluation system for complications based on severity and required intervention type and is suitable for the evaluation of surgery in a heterogeneous cohort. METHODS: A multi-institutional retrospective survey of 141 patients who underwent surgery for giant cell tumor of bone in the extremity was performed. The incidence and risk factors of complications, type of intervention for complication control, and impact of complications on functional and oncological outcomes were analyzed using the Dindo-Clavien classification. RESULTS: Forty-six cases (32.6%) had one or more complications. Of them, 18 (12.8%), 11 (7.8%), and 17 (12.1%) cases were classified as Dindo-Clavien classification grade I, II, and III complications, respectively. There were no cases with grade IV or V complications. Progression in Campanacci grading (p = 0.04), resection (over curettage, p