Kienbock's disease.

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Abstract

[Indexed for MEDLINE] 3. Biomolecules. 2024 Jun 6;14(6):667. doi: 10.3390/biom14060667. Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head. Zhang J(1), Cao J(1), Liu Y(1), Zhao H(2). Author information: (1)The First Clinical College of Medicine, Lanzhou University, Lanzhou 730000, China. (2)Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou 730000, China. Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic condition characterized by bone cell ischemia, necrosis, bone trabecular fracture, and clinical symptoms such as pain, femoral head collapse, and joint dysfunction that can lead to disability. The disability rate of ONFH is very high, which imposes a significant economic burden on both families and society. Steroid-associated osteonecrosis of the femoral head (SANFH) is the most common type of ONFH. However, the pathogenesis of SANFH remains unclear, and it is an urgent challenge for orthopedic surgeons to explore it. In this paper, the pathogenesis of SANFH and its related signaling pathways were briefly reviewed to enhance comprehension of the pathogenesis and prevention of SANFH. DOI: 10.3390/biom14060667 PMCID: PMC11202272