Interventions for congenital talipes equinovarus (clubfoot).

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: SB: none known. VP: has received consultancy fees, research grants and conference financial support for various activities unrelated to this study. EHB: none known. JB: Joshua Burns' research and clinical activities are funded by the Australian Department of Health (Medical Research Future Fund), US National Institutes of Health, Charcot‐Marie Tooth Association of Australia, Charcot‐Marie Tooth Association (USA), Diabetes Australia, Elizabeth Lottie May Rosenthal Bone Bequest, Perpetual Limited, Humpty Dumpty Foundation. Consultancies: Acceleron Pharma (Sept 2016). KG: none known. 4. J Pediatr Soc North Am. 2024 Oct 11;9:100130. doi: 10.1016/j.jposna.2024.100130. eCollection 2024 Nov. Prenatal Counseling for Congenital Clubfoot. Adhiyaman A(1), Tracey OC(1), Umesh A(1), Nian PP(1), Silverstein MK(2), Doyle SM(1), Scher DM(1). Author information: (1)Hospital for Special Surgery, New York, NY, USA. (2)East Side Women's ObGyn Associates, New York, NY, USA. Congenital clubfoot is a common deformity that affects 1 in 1000 newborns and is frequently detected prenatally during routine prenatal care. A wide variety of detection methods and testing are used to identify clubfoot and other congenital anomalies in the fetus, including complete ultrasonography, amniocentesis, chorionic villus sampling, or cell-free DNA. Newer studies have associated certain genome sequences to clubfoot specifically. It is important for orthopaedic surgeons to understand the implications of the various tests to provide the appropriate prenatal counseling. Early prenatal detection of clubfoot can help parents prepare for the demands of caring for a child with clubfoot and build trust between families and clinicians, ultimately leading to better, patient-centered care for their children. KEY CONCEPTS: (1)Prompt recognition and treatment of congenital clubfoot is imperative to facilitate optimal treatment.(2)Prenatal diagnosis usually consists of sonography of the plantar surface of both feet at 13-16 weeks' gestation.(3)Additional post-natal testing may be indicated in patients with neurological impairment or syndromic features.(4)Genetic markers such as PITX1, RBM10, HOX, and CASP (among others) have been identified as involved in clubfoot development and have implications on prenatal testing and counseling. © 2024 The Authors. DOI: 10.1016/j.jposna.2024.100130 PMCID: PMC12088293