Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.

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Abstract

[Indexed for MEDLINE] 3. Clin Spine Surg. 2022 Feb 1;35(1):E68-E76. doi: 10.1097/BSD.0000000000001113. Current Management of Cervical Spondylotic Myelopathy. Donnally CJ 3rd(1), Patel PD(2), Canseco JA(2), Vaccaro AR(2), Kepler CK(2). Author information: (1)Texas Spine Consultants, Addison, TX. (2)Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA. Cervical spondylotic myelopathy (CSM) develops insidiously as degenerative changes of the cervical spine impact the spinal cord. Unfortunately, CSM is a form of spinal cord injury in older patients that often experiences delayed treatment. This summary evaluates the pathophysiology, natural history, diagnosis, and current management of CSM. Frequently, patients do not appreciate or correlate their symptomatology with cervical spine disease, and those with radiographic findings may be clinically asymptomatic. Providers should remember the classic symptoms of CSM-poor hand dexterity, new unsteady gait patterns, new onset and progressive difficulty with motor skills. An magnetic resonance imaging is required in patients with suspected CSM, but computerized tomography myelography is an alternative in patients with implants as contraindications to magnetic resonance imaging. The management of those with CSM has continued to be a controversial topic. In general, patients with incidental findings of cervical cord compression that are asymptomatic can be managed conservatively. Those with daily moderate-severe disease that significantly affects activities of daily living should be treated operatively. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/BSD.0000000000001113