Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: All experimental protocols were approved by the Ethical Committee of Nanjing Jinling Hospital, the Affiliated Hospital of Nanjing University Medical School. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. 4. J Am Acad Orthop Surg. 2017 Apr;25(4):288-296. doi: 10.5435/JAAOS-D-15-00144. Isolated Head and Liner Exchange in Revision Hip Arthroplasty. Walmsley DW(1), Waddell JP, Schemitsch EH. Author information: (1)From the Division of Orthopaedic Surgery, Department of Surgery, Southlake Regional Health Centre, Newmarket, Ontario, Canada (Dr. Walmsley), the Division of Orthopaedic Surgery, Department of Surgery, St. Michael's Hospital, Toronto, Ontario, Canada (Dr. Waddell), and the Division of Orthopaedic Surgery, Department of Surgery, London Health Sciences Centre, London, Ontario, Canada (Dr. Schemitsch). As the number of primary total hip arthroplasties increases, so does the burden of revision procedures. The decision to revise well-fixed components in the setting of polyethylene wear and osteolysis is controversial. Modular head and liner exchange offers the advantages of reduced invasiveness, faster recovery, and bone preservation. These advantages come at the expense of higher rates of revision surgery for instability. Using the native locking mechanism for securing the new liner is preferred; however, cementing a liner into a well-fixed acetabular component is a practical alternative. The use of bone allograft or bone graft substitute for areas of osteolysis is controversial. In the setting of osteolysis, outcomes associated with the use of highly cross-linked polyethylene liners have been better than those associated with the use of conventional polyethylene; therefore, thinner liners and larger femoral heads can be used and reduce the risk of instability. DOI: 10.5435/JAAOS-D-15-00144