The biology of aseptic osteolysis.

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Abstract

[Indexed for MEDLINE] 10. JBJS Rev. 2016 Jul 5;4(7):e1. doi: 10.2106/JBJS.RVW.15.00081. Osteolysis Complicating Total Knee Arthroplasty. Gilbert TJ(1), Anoushiravani AA, Sayeed Z, Chambers MC, El-Othmani MM, Saleh KJ. Author information: (1)Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois. Osteolysis is a process mounted by the host immune system that relies on several variables, including patient-related factors, type of insert material, modes of wear, and implant design. Imaging techniques such as radiography, computed tomography (CT) scans, magnetic resonance imaging (MRI), and tomosynthesis aid in diagnosing osteolysis. Surgical options for the treatment of osteolysis include the insertion of bone grafts, bone cement, and prosthetic augmentation. Although no approved pharmacological therapies for the specific treatment of osteolysis exist, the use of bisphosphonates and statins decreases the risk of osteolysis. DOI: 10.2106/JBJS.RVW.15.00081