Particle bioreactivity and wear-mediated osteolysis.

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Abstract

[Indexed for MEDLINE] 20. Morphologie. 2017 Mar;101(332):1-8. doi: 10.1016/j.morpho.2016.06.001. Epub 2016 Jul 15. Wear products of total hip arthroplasty: The case of polyethylene. Massin P(1), Achour S(2). Author information: (1)Département de chirurgie orthopédique, hôpitaux universitaires Paris Nord Val-de-Seine, site Beaujon, 100, boulevard du General-Leclerc, 92110 Clichy, France. Electronic address: philippe.massin@aphp.fr. (2)Département de chirurgie orthopédique, hôpitaux universitaires Paris Nord Val-de-Seine, site Beaujon, 100, boulevard du General-Leclerc, 92110 Clichy, France. Among the bearing surfaces involved in a total hip arthroplasty, ultra-high molecular weight polyethylene (UHMWPE) is the weak link. It is submitted to the friction of a harder bearing, producing wear particles, which, in turn, initiate an inflammatory reaction ultimately leading to osteolysis. This kind of bone deterioration sometimes turns out to an aggressive granuloma and may provoke implant loosening. Wear resistance of UHMWPE depends on its molecular weight and crystallinity. Some steps of the manufacturing process were improved to optimize its tribological properties and to slow down degradation resulting from mechanical (abrasion) and chemical (oxidation) phenomena. Its preparation and conservation must be performed in an inert atmosphere, i.e. without ambient oxygen. Its resistance to abrasion depends on its cross-linking degree. Its cross-linking rate was observed to increase proportionally to the irradiation doses, improving its wear resistance. However, its mechanical properties are impaired and moreover, it becomes oxidation sensitive. It is therefore necessary to submit it to a thermal treatment to eliminate free radicals that were produced during irradiation. More recently impregnation by vitamin E, a powerful anti-oxidant product, was proposed to preserve the polymer from in vivo oxidation while maintaining its mechanical properties. We raised the hypothesis that last-generation UHMWPE could offer the same wear resistance as the most performing bearings (ceramic-on-ceramic). Recent clinical results confirm the tribological performance of highly crosslinked UHMWPE in vivo. However, it remains to be seen whether this excellent wear resistance would persist under eccentric load such as edge loading, and if, in the long run, this kind of bearing proves capable of reducing the risk of osteolysis in young and active patients. Copyright © 2016 Elsevier Masson SAS. All rights reserved. DOI: 10.1016/j.morpho.2016.06.001