Genetic Analysis and Sonography Characteristics in Fetus with SHOX Haploinsufficiency.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 6. Zhongguo Gu Shang. 2017 Oct 25;30(10):976-978. doi: 10.3969/j.issn.1003-0034.2017.10.020. [Progress on research of Madelung's deformity]. [Article in Chinese] Song YX(1), Wang ZP(1), Liu L(2), Xue W(1), Hao ZY(1), Zhang QL(1), She W(1), Cai LY(1), Gou HT(1), Qian YW(1). Author information: (1)The 2nd Department of Orthopaedics, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China. (2)The 2nd Department of Orthopaedics, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China; liulin3669@163.com. Madelung deformity is a rare deformity of forearm and wrist caused by growth disorders of distal radius ulnar and palmar epiphyseal. Current studies showed that its incidence mainly associated with trauma, epiphyseal developmental abnormalities, nutritional disorders and genetic deletion or mutation. The early clinical presentation is not typical, in middle and late time, wrist deformity and weak can appear. Plain film considered as the main means of diagnosis is often lack of early diagnosis significance. Although wrist joint magnetic resonance imaging showing early soft tissue and skeletal abnormalities were used for the early diagnosis of the disease, current domestic study in magnetic resonance imaging of this deformity is less. According to the size of the distal ulnar inclination angle and palm angle, this deformity can be divided into different types. The patients with severe deformity and symptoms usually need surgical intervention including ulna revision and osteotomy of the distal radius at present. Although the two operation can achieve good clinical results, the surgical trauma, infection and postoperative risk of joint activities are more. Copyright© 2017 by the China Journal of Orthopaedics and Traumatology Press. DOI: 10.3969/j.issn.1003-0034.2017.10.020