Bacteriophage therapy for bone and joint infections.

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Abstract

[Indexed for MEDLINE] 15. Curr Osteoporos Rep. 2007 Sep;5(3):120-7. doi: 10.1007/s11914-007-0027-8. Cancer-associated bone disease. Brown SA(1), Guise TA. Author information: (1)Department of Medicine, University of Virginia,P.O. Box 801420, Charlottesville, VA 22908, USA. sab2f@virginia.edu Patients with cancer are at risk for many events involving the skeleton, including metastatic disease of bone and treatment-related bone loss. Cancer-related therapies that can affect bone include hormonal therapy, chemotherapy, and the use of glucocorticoids. Screening for bone loss, with lifestyle modifications and the early use of anti-osteoporosis therapies such as bisphosphonates, may decrease bone loss and reduce the risk of fracture. This article reviews risk factors and mechanisms associated with cancer-related bone loss and metastases as well as strategies for the detection of bone-related complications of cancer and therapies to treat these complications. This article focuses on the more common cancers with adverse skeletal effects: breast cancer, prostate cancer, and multiple myeloma. DOI: 10.1007/s11914-007-0027-8